Publications by authors named "Mark R Spyvee"
Article Synopsis
- E7974 is a synthetic version of a compound from marine sponges called hemiasterlin, and it works by disrupting tubulin, which is essential for cell division.
- Like vinblastine, E7974 inhibits tubulin polymerization and causes cancer cells to stop dividing, leading to cell death (apoptosis) after prolonged blocking in the G2-M phase of the cell cycle.
- The drug primarily targets alpha-tubulin rather than beta-tubulin, suggesting that E7974 and similar compounds might have a unique mechanism of action among tubulin-targeting anticancer drugs.
Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.
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