Publications by authors named "Mark P van Opijnen"

This case shows the feasibility of targeted muscle reinnervation (TMR) in a patient with a traumatic neuroma of the medial antebrachial cutaneous nerve (MABCN). TMR was performed by connecting the proximal stump of the MABCN to the branch innervating the accessory epitrochleoanconeus muscle. Postoperatively, the patient reported significantly less pain.

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Purpose: Previous evidence suggests that glioma re-resection can be effective in improving clinical outcomes. Furthermore, the use of mapping techniques during surgery has proven beneficial for newly diagnosed glioma patients. However, the effects of these mapping techniques during re-resection are not clear.

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For glioblastoma patients, the efficacy-targeted therapy is limited to date. Most of the molecular therapies previously studied are lacking efficacy in this population. More trials are needed to study the actual actionability of biomarkers in (recurrent) glioblastoma.

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Article Synopsis
  • * The review analyzes existing frameworks for informed consent in WGS related to oncology, noting their advantages and drawbacks.
  • * It emphasizes the need for customized informed consent tailored specifically to the unique challenges faced by glioblastoma patients, considering their disease rarity, prognosis, and cognitive effects.
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Purpose: Next generation sequencing (NGS) is an important tool used in clinical practice to obtain the required molecular information for accurate diagnostics of high-grade adult-type diffuse glioma (HGG). Since individual centers use either in-house produced or standardized panels, interlaboratory variation could play a role in the practice of HGG diagnosis and treatment. This study aimed to investigate the current practice in NGS application for both primary and recurrent HGG.

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Background: Despite current best treatment options, a glioblastoma almost inevitably recurs after primary treatment. However, in the absence of clear evidence, current guidelines on recurrent glioblastoma are not well-defined. Re-resection is one of the possible treatment modalities, though it can be challenging to identify those patients who will benefit.

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Article Synopsis
  • Glioblastoma (GBM) is a deadly brain tumor with no effective standard treatment upon recurrence, prompting a need for improved strategies to manage this challenging condition.
  • The GLOW study aims to include whole genome sequencing (WGS) in the standard care for GBM patients, providing tailored treatment options based on genetic insights, in collaboration with various Dutch medical centers.
  • The study will analyze outcomes based on the percentage of patients receiving targeted therapies informed by WGS, their overall survival, and other success rates, aiming to enhance treatment protocols for those facing this aggressive cancer.
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Background: Traumatic neuromata often recur after resection. Recently, targeted muscle reinnervation (TMR) has been shown to be a promising alternative for the treatment of traumatic neuroma, also in nonamputees. This case shows that TMR can also be applied for this indication in recurrent traumatic neuroma.

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Article Synopsis
  • IDH1/2 wildtype (IDHwt) gliomas classified as lower-grade (WHO grade 2 and 3) with certain genetic mutations exhibit similar survival rates to IDHwt glioblastoma, leading to both being categorized as glioblastoma IDHwt by WHO 2021.
  • A study analyzed epilepsy in these two groups, focusing on the number of patients developing epilepsy, the timing of onset, and the treatment approaches used for managing seizures.
  • Results indicated that while the overall incidence of epilepsy is comparable, IDHwt hLGG patients experience earlier onset and longer diagnosis delays compared to IDHwt glioblastoma patients, suggesting differing clinical pathways for these glioma subtypes.
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Article Synopsis
  • The study aimed to compare the effectiveness of two antiepileptic drugs, lamotrigine and lacosamide, in treating seizures in brain tumor patients after initial treatments failed.
  • Researchers analyzed data from 139 patients with diffuse glioma who received either drug and assessed treatment failure rates, uncontrolled seizures, and toxicity levels.
  • Results indicated no significant difference between the two medications in terms of treatment failure or seizure control, suggesting both are equally effective for this patient group.
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Patients with melanoma brain metastases (MBM) still have a very poor prognosis. Several treatment modalities have been investigated in an attempt to improve the management of MBM. This review aimed to evaluate the impact of current treatments for MBM on patient- and tumor-related outcomes, and to provide treatment recommendations for this patient population.

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