Publications by authors named "Mark Obonyo"

Article Synopsis
  • People in the Lake Nakuru area of Kenya are worried about diseases that can spread from animals to humans, called zoonoses.
  • They learned about these diseases through discussions in their community and interviews with local health and veterinary workers.
  • The most talked-about disease was anthrax, and many participants believed that eating uninspected meat could lead to infections.
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Live bird markets (LBMs) provide integral hubs for 95% of poultry produced for food. Surveillance systems in LBMs serving smallholder farmers in sub-saharan Africa are often non-functional, and data about public health risks and emerging pathogens are lacking. Studies in Kenya have reported 29-44% Campylobacter prevalence in poultry.

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Introduction: anthrax is endemic in some parts of Kenya causing mortalities in livestock and morbidity in humans. On January 20, 2018, news media reported suspected anthrax in a remote southern Kenyan village after villagers became ill following consumption of meat from a dead cow that was confirmed, by microscopy, to have died of anthrax. We assessed community knowledge, attitude and practices (KAP) to identify intervention gaps for anthrax prevention.

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Animal health service providers can play an important role in limiting drug resistance by promoting responsible and prudent use of veterinary drugs. Recognizing this potential, international agencies and governments have called for these providers to receive drug stewardship training, particularly providers in low- and middle-income countries where top-down regulations (e.g.

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Background: In 2014, Kenya's Field Epidemiology and Laboratory Training Program (FELTP) initiated a 3-month field-based frontline training, Field Epidemiology Training Program (FETP-F), for local public health workers.

Objective: This study aimed to measure the effect of FETP-F on participant workplace practices regarding quality and consistency of public health data, critical interaction with public health data, and improvements in on-time reporting (OTR).

Methods: Between February and April 2017, FELTP conducted a mixed methods evaluation via online survey to examine outcomes achieved among all 215 graduates from 2014 and 2015.

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Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging viral disease and dromedary camels are known to be the source of human spill over events. A cross-sectional epidemiological surveillance study was carried out in Kenya in 2017 to, 1) estimate MERS-CoV antibody seropositivity in the camel-dense counties of Turkana, Marsabit, Isiolo, Laikipia and Nakuru to identify, and 2) determine the risk factors associated with seropositivity in camels. Blood samples were collected from a total of 1421 camels selected using a multi-stage sampling method.

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Introduction: in 2015, a cholera outbreak was confirmed in Nairobi county, Kenya, which we investigated to identify risk factors for infection and recommend control measures.

Methods: we analyzed national cholera surveillance data to describe epidemiological patterns and carried out a case-control study to find reasons for the Nairobi county outbreak. Suspected cholera cases were Nairobi residents aged >2 years with acute watery diarrhea (>4 stools/≤12 hours) and illness onset 1-14 May 2015.

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Background: Globally, under-nutrition accounts for > 3 million deaths annually among children < 5 years, with Kenya having ~ 35,000 deaths. This study aimed to identify factors associated with malnutrition in children aged < 5 years in western Kenya.

Methods: We conducted a hospital-based unmatched case-control study between May and June 2017.

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Article Synopsis
  • Cholera is still a significant health issue in Kenya, particularly in Isiolo County, despite public awareness efforts; understanding the community's knowledge, attitudes, and practices (KAP) is crucial for effective prevention.
  • A mixed-methods study was conducted with 428 participants, revealing that while most had heard of cholera and understood its communicability, many were not treating their drinking water or practicing good sanitation.
  • Factors associated with higher knowledge scores included having a positive attitude, treating drinking water, being younger than 36, and having formal education, while focus group discussions identified poor latrine access and cultural beliefs as challenges to cholera prevention.
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Background: Cutaneous leishmaniasis is a neglected disease known to cause significant morbidity among the poor. We investigated a suspected outbreak to determine the magnitude of cases, characterize the cases and identify risk factors of cutaneous leishmaniasis in Gilgil, a peri-urban settlement in Central Kenya.

Methods: Hospital records for the period 2010-2016 were reviewed and additional cases were identified through active case search.

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Background: Leptospirosis is a neglected zoonosis of public health importance transmitted through contact with contaminated soil, water or urine of infected animals. In pigs the disease is characterized by abortion, still births and weak piglets. A cross-sectional study was conducted in May to July 2018 to estimate the sero-prevalence of leptospirosis and factors associated with seropositivity in slaughter pigs.

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Background: Cholera globally affects 1.3-4.0 million people and causes 21 000-143 000 deaths annually.

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Introduction: Freshwater vector snails' distribution, infection with cercariae, preferred habitat and possible trematodiases transmission foci is not well known in Western Kenya. We sought to determine the distribution and prevalence of infection of snails per agro-ecological zone and environmental factors in vector snail habitats.

Methods: We conducted a cross-sectional survey from March, 2016 - May, 2016, harvested and identified snails using shell morphology, determined their infection with trematode cercariae using microscopy, used descriptive statistics to estimate the prevalence of infection and relationship between snail abundance and environmental factors.

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Kenya is one of 22 countries globally that account for 90% of all HIV-positive pregnant women. This study aimed to determine factors affecting uptake of prevention of mother-to-child transmission (PMTCT) services among HIV-positive pregnant women at Lodwar County Referral Hospital in Turkana County, an arid area in northern Kenya. We conducted a retrospective review of HIV-positive pregnant women attending antenatal care (ANC) and accessing PMTCT services between January 2015 and December 2016.

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In Kenya, human anthrax cases most often occur linked to animal anthrax. In most cases, human behaviors, especially slaughter and consumption of meat from animal anthrax cases, has been implicated. This case study is based on an anthrax outbreak investigation conducted in an endemic region in Kenya in May 2016.

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Article Synopsis
  • Unadulterated milk is crucial for both health and industrial purposes, as antimicrobial residues can lead to drug resistance and allergies, especially in raw milk sold in Lamu West Sub-County, Kenya.
  • A study involving 152 vendors and 207 farmers revealed that a significant percentage of raw milk samples tested positive for antimicrobial residues (15.5% from farmers and 18.4% from vendors) and were often adulterated with water.
  • Increased awareness among farmers about the risks of antimicrobial residues and training on proper milking practices significantly reduced the likelihood of selling contaminated milk, highlighting the need for regular milk testing and education.
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Introduction: in February 2015, an outbreak of acute watery diarrhea was reported in two sub counties in western Kenya. e 01 serotype Ogawa was isolated from 26 cases and from water samples collected from a river mainly used by residents of the two sub-counties for domestic purposes. We carried out an investigation to determine factors associated with the outbreak.

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Introduction: species, a zoonotic enteric coccidian parasite, is among the leading causes of diarrhea in children. We evaluated the prevalence of infections in calves, factors associated with calf infection, environmental contamination of manure by and factors that expose humans to zoonotic transmission in Asembo.

Methods: in a cross-sectional study conducted from January to July 2015, we collected fecal specimens from 350 randomly selected calves aged ≤ 6 months old and 187 manure samples from the same farms.

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Article Synopsis
  • The recent Zika outbreak and Ebola epidemic have underscored the need for improved preparedness in detecting and responding to public health threats, particularly those from animal origins.
  • One-Health approaches, which facilitate collaboration between human, animal, and environmental health sectors, are seen as essential for preventing and managing disease outbreaks.
  • This text discusses three significant initiatives in Kenya that are advancing the implementation of the One Health strategy.
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Article Synopsis
  • - Dadaab Refugee Camp in Kenya is home to approximately 340,000 refugees and faced a cholera outbreak starting in November 2015, when two residents showed symptoms of acute watery diarrhea linked to Vibrio cholerae.
  • - Following the initial cases, there was a swift escalation, with 45 more confirmed cases reported within a week, prompting a coordinated response from various health organizations, including the UN, Médecins Sans Frontières, and local health authorities.
  • - To mitigate future cholera risks, it's crucial to enhance water, sanitation, and hygiene facilities, as well as to improve disease surveillance systems in the camp and its surrounding areas.
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Background: Human animal-bite injuries are a serious public health problem due to associated risk for rabies virus exposure. Animal-bite injuries especially dog bites are useful indicators for assessing the risk of rabies virus transmission and need for rabies post exposure prophylaxis (PEP). Understanding the epidemiology and surveillance of animal bites and rabies post-exposure prophylaxis is critical in implementing Kenya's national rabies elimination strategy.

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Background: From December 2014 to September 2016, a cholera outbreak in Kenya, the largest since 2010, caused 16,840 reported cases and 256 deaths. The outbreak affected 30 of Kenya's 47 counties and occurred shortly after the decentralization of many healthcare services to the county level. This mixed-methods study, conducted June-July 2015, assessed cholera preparedness in Homa Bay, Nairobi, and Mombasa counties and explored clinic- and community-based health care workers' (HCW) experiences during outbreak response.

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The first laboratory confirmed dengue outbreak in Kenya was reported in coastal towns of Malindi and Kilifi in 1982. Since then, no other outbreak had been confirmed in Kenya. Dengue outbreak was confirmed among African Mission soldiers in Somalia (AMISOM) between May to October 2011.

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Introduction: Metabolic syndrome affects 20-25% of the adult population globally. It predisposes to cardiovascular disease and Type 2 diabetes. Studies in other countries suggest a high prevalence of metabolic syndrome among HIV-infected patients but no studies have been reported in Kenya.

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