Publications by authors named "Mark N Ragheb"
Article Synopsis
- RNAP faces obstacles during transcription that impact its movement, requiring assistance from associated factors like the protein Mfd.
- Mfd, known for DNA repair, is also important in regulating transcription and influences RNAP's association with chromosomal regions, often causing increased RNAP pausing in harder-to-transcribe areas.
- Mfd's regulation primarily affects regions with complex regulatory RNAs, which are involved in various biological functions and can influence mutagenesis, indicating its role in promoting evolution within certain genetic systems.
Efforts to battle antimicrobial resistance (AMR) are generally focused on developing novel antibiotics. However, history shows that resistance arises regardless of the nature or potency of new drugs. Here, we propose and provide evidence for an alternate strategy to resolve this problem: inhibiting evolution.
View Article and Find Full Text PDFBackground: Mycobacterial interspersed repetitive units (MIRUs) are minisatellites within the Mycobacterium tuberculosis (Mtb) genome. Copy number variation (CNV) in MIRU loci is used for epidemiological typing, making the rate of variation important for tracking the transmission of Mtb strains. In this study, we developed and assessed a whole-genome sequencing (WGS) approach to detect MIRU CNV in Mtb.
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