Publications by authors named "Mark Montine"
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies.
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- The text discusses open-source tools designed for 3D analysis of photographs from dissected human brain slices, which are often underutilized for quantitative studies.
- These tools can reconstruct a 3D volume and segment brain images into 11 regions per hemisphere, serving as a cost-effective alternative to traditional MRI imaging.
- Testing shows that the methodology provides accurate 3D reconstructions and can differentiate between Alzheimer's disease cases and healthy controls, with tools available in the FreeSurfer suite.
Article Synopsis
- Open-source tools have been developed for 3D analysis of brain slice photographs, which are often underutilized for quantitative research.
- These tools can 3D reconstruct brain volumes and segment them into 22 regions, independent of slice thickness, serving as a viable alternative to costly MRI scans.
- Tests on data from Alzheimer's Disease Research Centers show that the tools provide accurate reconstructions and detect differences related to Alzheimer's, with results comparable to those obtained from MRI.
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive and stereotyped accumulation of protein aggregates, but the underlying molecular and cellular mechanisms driving AD progression and vulnerable cell populations affected by disease remain coarsely understood. The current study harnesses single cell and spatial genomics tools and knowledge from the BRAIN Initiative Cell Census Network to understand the impact of disease progression on middle temporal gyrus cell types.
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