IMPACT OF NOCTURNAL OXYGEN ENRICHMENT ON HIGH-ALTITUDE ACCLIMATIZATION.

Nocturnal oxygen enrichment improves sleep at high-altitude but may impair acclimatization. Determine if nocturnal oxygen enrichment impacts acclimatization. A 7-day acclimatization protocol occurred at a field-based research site between 0-4200m.

The combined influences of local heat application and resistance exercise on the acute mRNA response of skeletal muscle.

Introduction: The development and maintenance of the skeletal muscle is crucial for the support of daily function. Heat, when applied locally, has shown substantial promise in the maintenance of the muscle. The purpose of this study was to determine the combined effects of local heat application and acute resistance exercise on gene expression associated with the human muscle growth program.

Influence of topical menthol gel on thermoregulation and perception while walking in the heat.

Purpose: Menthol is known to elicit opposing thermoregulatory and perceptual alterations during intense exercise. The current purpose was to determine the thermoregulatory and perceptual effects of topical menthol application prior to walking in the heat.

Methods: Twelve participants walked (1.

The isolated effects of local cold application on proteolytic and myogenic signaling.

Post-exercise cooling studies reveal inhibitory effects on markers of skeletal muscle growth. However, the isolated effect of local cold application has not been adequately addressed. It is unclear if the local cold or the combination of local cold and exercise is driving negatively altered skeletal muscle gene expression.

The independent effects of local heat application on muscle growth program associated mRNA and protein phosphorylation.

The development and maintenance of skeletal muscle is crucial for the support of daily function. Recent evidence suggests that genes coded for proteins associated with the human muscle growth program (myogenic and proteolytic genes) are sensitive to local heat application. Therefore, the purpose of this investigation was to determine the effect of 4 h of local heat application to the vastus lateralis at rest on acute phosphorylation (mTOR, p70-S6K1, and 4E-BP1) and gene expression changes for proteins associated with the muscle growth program.

Influence of topical capsaicin cream on thermoregulation and perception during acute exercise in the heat.

Purpose: Determine if topical capsaicin, a transient receptor potential vanilloid heat thermoreceptor activator, alters thermoregulation and perception when applied topically prior to thermal exercise.

Methods: Twelve subjects completed 2 treatments. Subjects walked (1.

No Mitochondrial Related Transcriptional Changes in Human Skeletal Muscle after Local Heat Application.

The purpose of the study is to determine the impact of local heating on skeletal muscle transcriptional response related to mitochondrial biogenesis and mitophagy. Twelve healthy subjects (height, 176.0 ± 11.

Influence of Local Muscle Cooling on Mitochondrial-Related Gene Expression at Rest.

The purpose of this study was to determine the impact of localized cooling of the skeletal muscle during rest on mitochondrial related gene expression. Thermal wraps were applied to the of each limb of 12 participants. One limb received a cold application (randomized) (COLD), while the other did not (RT).

Heat Acclimation in Females Does Not Limit Aerobic Exercise Training Outcomes.

Recent aerobic exercise training in the heat has reported blunted aerobic power improvements and reduced mitochondrial-related gene expression in men. It is unclear if this heat-induced blunting of the training response exists in females. The purpose of the present study was to determine the impact of 60 min of cycling in the heat over three weeks on thermoregulation, gene expression, and aerobic capacity in females.

Effect of local heat application during exercise on gene expression related to mitochondrial homeostasis.

The aim of this study was to determine the impact of local muscle heating during endurance exercise on human skeletal muscle mitochondrial-related gene expression. Twelve subjects (25 ± 6 yr, 177 ± 8 cm, 78 ± 16 kg, and peak aerobic capacity 45 ± 8 mL·kg·min) cycled with one leg heated (HOT) and the other serving as a control (CON). Skin and intramuscular temperatures were taken before temperature intervention (Pre), after 30 minutes (Pre30), after exercise (Post) and four hours after exercise (4Post).

The Acute Effects of Exercise and Temperature on Regional mtDNA.

A reduced mitochondrial DNA (mtDNA) copy number, the ratio of mitochondrial DNA to genomic DNA (mtDNA:gDNA), has been linked with dysfunctional mitochondria. Exercise can acutely induce mtDNA damage manifested as a reduced copy number. However, the influence of a paired (exercise and temperature) intervention on regional mtDNA (MINor Arc and MAJor Arc) are unknown.

Acute effects of functional dry needling on skeletal muscle function.

Introduction: Functional dry needling (FDN) is commonly used to treat soft tissue pain-related conditions. Previous research has demonstrated benefits to chronic resistance training; however, objective physiological measures sensitive to acute exercise have not been found. The purpose of this study was to evaluate the acute effects of FDN on muscle strength and endurance.

Effect of local cold application during exercise on gene expression related to mitochondrial homeostasis.

Exercise training increases mitochondrial content in active skeletal muscle. Previous work suggests that mitochondrial-related genes respond favorably to exercise in cold environments. However, the impact of localized tissue cooling is unknown.

Exercise- and Cold-Induced Human mRNA Isoform Specific Responses.

Cold exposure in conjunction with aerobic exercise stimulates gene expression of , the master regulator of mitochondrial biogenesis. can be expressed as multiple isoforms due to alternative splicing mechanisms. Among these isoforms is , which produces a truncated form of the protein, as well as isoforms derived from the first exon of the transcript, , , and .

Randomized controlled pilot study of customized pamphlets to promote physical activity and symptom self-management in women with multiple sclerosis.

Objective: Investigate the feasibility and potential efficacy of a customized print-based intervention to promote physical activity and symptom self-management in women with multiple sclerosis.

Design: A randomly allocated two-group repeated measures design, with a delayed-treatment contact group serving as the control. Participants were randomized to receive the intervention immediately (n =14) or receive it at week 12 (n =16).

A Model of Community-Based Behavioral Intervention for Depression in Diabetes: Program ACTIVE.

Depression affects one in four people with diabetes and significantly affects diabetes health. Earlier studies of the treatment of depression have documented that cognitive behavioral therapy (CBT) and exercise have each been found to be effective in treating depression in people with and without diabetes in the context of medical settings. Individuals in rural areas lack regular access to medical centers and require treatment options that may be adapted for local communities.