Publications by authors named "Mark MacDonald"

Article Synopsis
  • A study aimed to use deep learning on brain MRI scans to predict 8-month survival rates for glioblastoma patients after radiotherapy, involving data from 206 patients diagnosed across UK centers.
  • The model's performance was tested against both imaging data (from MRI scans) and non-imaging data (like demographics) and showed high accuracy, particularly with imaging data outperforming non-imaging data.
  • This deep learning model can help identify glioblastoma patients at higher risk of early mortality, potentially guiding them towards early second-line treatments or clinical trials.
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Purpose: The purpose of this study was to determine whether ankle brace use in university-level varsity volleyball athletes affected their 3-step spike jump height and whether certain types of ankle braces have a greater effect on jump height.

Methods: Nine male university-level varsity volleyball athletes participated in a repeated-measures design study in which each athlete performed three 3-step volleyball spike jumps in 3 ankle brace conditions (soft, rigid, and no brace). Vertical jump height was measured by the Vertec device and video motion analysis at a university biomechanics research laboratory.

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Objectives: To investigate the impact of depression and its treatment on health-related quality of life (HRQoL) in a naturalistic, primary care setting in the UK.

Methods: The Factors Influencing Depression Endpoints Research (FINDER) study was a European, 6-month, prospective, observational study designed to estimate HRQoL in patients with a clinical diagnosis of depression. This paper examines primary care patients recruited in the UK.

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The applications of lanthanide-doped upconversion nanocrystals in biological imaging, photonics, photovoltaics and therapeutics have fuelled a growing demand for rational control over the emission profiles of the nanocrystals. A common strategy for tuning upconversion luminescence is to control the doping concentration of lanthanide ions. However, the phenomenon of concentration quenching of the excited state at high doping levels poses a significant constraint.

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This work presents a combined approach of kinetic control and thermodynamic selection for the synthesis of monodisperse 19 gold atom nanoclusters protected by thiolate groups. The step of kinetic control allows the formation of a proper size distribution of initial size-mixed Au(n)(SR)(m) nanoclusters following the reduction of a gold precursor. Unlike the synthesis of Au(25)(SR)(18) nanoclusters, which involves rapid reduction of the gold precursor by NaBH(4) followed by size focusing, the synthesis of 19-atom nanoclusters requires slow reduction effected by a weaker reducing agent, borane-tert-butylamine complex.

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Herein, we present the structural characterization of the core and surface of colloidally stable ultrathin bismuth sulfide (Bi(2)S(3)) nanowires using X-ray Absorption Spectroscopy (EXAFS and XANES), X-ray Photoelectron Spectroscopy (XPS), and Nuclear Magnetic Resonance (NMR). These three techniques allowed the conclusive structural characterization of the inorganic core as well as the coordination chemistry of the surface ligands of these structures, despite the absence of significant translational periodicity dictated by their ultrathin diameter (1.6 nm) and their polycrystallinity.

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Two experiments explored the neural mechanisms underlying the learning and consolidation of novel spoken words. In Experiment 1, participants learned two sets of novel words on successive days. A subsequent recognition test revealed high levels of familiarity for both sets.

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Impaired manual functioning often occurs when the hands are exposed to cold temperatures, but the underlying mechanism is not clearly understood. Tactile feedback is thought to provide important information during object manipulations in order to scale and regulate grip forces; however, topical anaesthetic-induced tactile sensation impairments may not realistically simulate the systemic neuromuscular impairment of the whole hand that could occur during cold temperature exposure. In two experiments, we studied the impact of (1) local hand cooling [thermoneutral finger skin temperature, cold (<8 degrees C)] and (2) core body temperature (thermoneutral core body temperature, pre-heated by 0.

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Destruction of the nasal septum and nasal bones by Mycobacterium leprae and subsequent infection is still seen regularly in leprosy endemic areas. The social stigma associated with this deformity is significant. Many different procedures have been developed to reconstruct the nose.

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One hundred and fifty-six opponensplasties carried out on 115 patients at Anandaban Hospital between 1987 and 1997 were reviewed. In most cases a flexor digitalis superficialis opponensplasty was performed. The outcome was assessed by measuring the finger to which the thumb could obtain a pinch grip, the gap between the thumb and little metacarpophalangeal joints, and the satisfaction of the patient.

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