Publications by authors named "Mark M Hahn"

Article Synopsis
  • The study investigates the effectiveness of ceftobiprole medocaril as a treatment for lethal pneumonic tularemia, a significant biothreat agent.
  • In a rat model, the drug showed a 92% survival rate 31 days after infection, comparable to another antibiotic, levofloxacin, while all placebo-treated rats died.
  • Analysis of infected tissues revealed that ceftobiprole medocaril effectively reduced bacterial load and prevented infection in surviving rats, indicating its potential as a countermeasure for severe tularemia cases.
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Under environmental stress, plants and algae employ a variety of strategies to protect the photosynthetic apparatus and maintain photostasis. To date, most studies on stress acclimation have focused on model organisms which possess limited to no tolerance to stressful extremes. We studied the ability of the Antarctic alga Chlamydomonas sp.

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Salmonella enterica serovar Typhi causes chronic infections by establishing biofilms on cholesterol gallstones. The production of extracellular polymeric substances (EPSs) is key to biofilm development, and biofilm architecture depends on which EPSs are made. The presence and spatial distribution of EPSs produced and were investigated in Salmonella enterica serovar Typhimurium and .

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The ability of subspecies serovar Typhi ( Typhi) to cause chronic gallbladder infections is dependent on biofilm growth on cholesterol gallstones. Non-typhoidal (e.g.

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Article Synopsis
  • The text discusses the diversity among various subspecies and serovars, noting their differences in host ranges and pathogenicity, yet highlighting their common ability to form biofilms and cause various types of diseases.
  • It emphasizes that outcomes of infections are influenced by factors like the microbe's growth state, environmental conditions, and the host's immune response, particularly during initial infections.
  • The review also explores the immune responses to both typhoidal and non-typhoidal salmonellae, pointing out knowledge gaps in intestinal and hepatobiliary immunity, and suggests new research directions in understanding chronic infections.
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Asymptomatic carriage of Salmonella Typhi continues to facilitate the transmission of typhoid fever, resulting in 14 million new infections and 136,000 fatalities each year. Asymptomatic chronic carriage of S. Typhi is facilitated by the formation of biofilms on gallstones that protect the bacteria from environmental insults and immune system clearance.

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serovar Typhi causes 14.3 million acute cases of typhoid fever that are responsible for 136,000 deaths each year. Chronic infections occur in 3%-5% of those infected and Typhi persists primarily in the gallbladder by forming biofilms on cholesterol gallstones, but how these bacterial communities evade host immunity is not known.

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Many of the deadliest bacterial diseases that plague humanity in the modern age are caused by bacterial biofilms that produce chronic infections. However, most of our knowledge of the host immune response comes from the study of planktonic pathogens. While there are similarities in the host response to planktonic and biofilm bacteria, specific immune responses toward biofilms have not been well studied; the only apparent difference is the inability to clear the bacteria allowing the biofilm infection to become chronic.

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