Publications by authors named "Mark Louie Ramos"
Article Synopsis
- About 10% of people with myeloid malignancies have a genetic predisposition, and a study used a genome-first approach to investigate this.
- They analyzed eight specific genes associated with myeloid malignancy risk in a large sample of individuals from two databases, discovering high odds of developing these cancers and reduced survival rates among those with harmful genetic variants.
- The most frequently found variant was in the DDX41 gene, which dramatically increased the likelihood of developing myeloid malignancies and also raised the risk of overall mortality among those affected.
Chromatin dynamics are central to the regulation of gene expression and genome stability. In order to improve understanding of the factors regulating chromatin dynamics, the genes encoding these factors are deleted and the differential gene expression profiles are determined using approaches such as RNA sequencing. Here, we analyzed a gene expression dataset aimed at uncovering the function of the relatively uncharacterized chromatin regulator, Set4, in the model system Saccharomyces cerevisiae (budding yeast).
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