Publications by authors named "Mark L Chicote"
Article Synopsis
- Menstrually related mood disorder (MRMD) is characterized by severe emotional symptoms occurring in the late luteal phase of the menstrual cycle, which may be linked to low levels of the neuroactive steroid allopregnanolone due to lesser conversion from progesterone.
- In a study with nine women with MRMD and fourteen healthy controls, MRMD was diagnosed using the DSM-5 criteria, and symptoms of depression and anxiety, as well as plasma neuroactive steroid levels, were assessed at different phases of the menstrual cycle.
- Results showed that while women with MRMD had higher allopregnanolone levels in the mid-follicular phase, they experienced greater depression severity only in the late luteal phase, suggesting a
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver condition, and the study aimed to differentiate between simpler steatosis and the more severe nonalcoholic steatohepatitis (NASH) using CT texture analysis.
- Sixteen NAFLD patients underwent liver biopsies and CT scans to analyze gray-level texture features, finding that those with NASH had distinct CT texture results compared to those with simple steatosis.
- The results indicated that lower entropy and mean pixel values could reliably predict NASH, suggesting that CT texture analysis could be an innovative tool for assessing liver disease progression.
Article Synopsis
- Overweight and obesity are linked to a deficiency in growth hormone (GH), which contributes to nonalcoholic fatty liver disease (NAFLD), a condition with limited treatment options.
- Researchers conducted a 6-month trial where 53 adults with NAFLD were randomly assigned to receive either low-dose GH or a placebo, focusing on reducing fat in the liver.
- Results showed that GH administration significantly decreased liver fat more than the placebo, without negatively affecting blood sugar levels, suggesting GH could be a potential treatment for NAFLD.
Objective: The GH and IGF-1 axis is a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) given its lipolytic, anti-inflammatory and anti-fibrotic properties. IGF-1 receptor (IGF-1R) and GH receptor (GHR) expression in adult, human hepatic tissue is not well understood across the spectrum of NAFLD severity. Therefore, we sought to investigate hepatic IGF-1R and GHR expression in subjects with NAFLD utilizing gene expression analysis (GEA) and immunohistochemistry (IHC).
View Article and Find Full Text PDFContext: Obesity is a state of relative growth hormone (GH) deficiency, and GH has been identified as a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) because of its lipolytic and anti-inflammatory properties. However, the GH/IGF-1 axis has not been well characterized in NAFLD.
Objective: We aimed to investigate serum GH and IGF-1 levels in relation to intrahepatic lipid content (IHL) and markers of hepatocellular damage and fibrosis in NAFLD.