Publications by authors named "Mark K Ogawa"
Article Synopsis
- A model utilizing alumina (Al(2)O(3)), steroids, and ethanol is developed for testing corticosteroids' stability in pressurized metered-dose inhalers (pMDIs), focusing on how these substances interact under stress conditions.*
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- The study identifies that corticosteroids with a C21-OH group are more reactive to Al(2)O(3), highlighting the necessity for aluminum canisters with an inert coating to maintain stability.*
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- The research also outlines the degradation pathways for specific corticosteroids and demonstrates that the model accurately predicts the degradation profile of beclomethasone dipropionate (BDP) consistent with actual product observations.*
