Publications by authors named "Mark James Wilsher"
Article Synopsis
- - Adenosquamous proliferation (ASP) is identified by two types of cells, glandular and squamous, found in specific breast lesions that exhibit sclerosing characteristics, excluding sclerosing adenosis.
- - ASP is linked to a variety of breast lesions, known as sclerosing lesions (SL) and breast lesions with sclerosis (BLWS), which can have different names despite being similar in structure and appearance.
- - There is a notable relationship between SL/BLWS and low-grade metaplastic carcinoma, specifically low-grade adenosquamous carcinoma (LGASC), as both share similar histological features, suggesting a possible connection in their development.
Article Synopsis
- The study investigates the presence of Rosai-Dorfman-type histiocytes (RDH) in sinonasal tissue from patients with eosinophilic chronic rhinosinusitis (ECR) to explore their clinical significance.
- A total of 10 sinonasal biopsies showing RDH were analyzed over two and a half years, with findings from an additional 21 ECR cases reviewed to assess RDH presence.
- The results indicate that RDH are associated with disease recurrence in ECR cases, suggesting they may play a significant role in the condition's persistence and response.
Low grade adenosquamous carcinoma (LGASC) is rare but commonly reported to arise in association with benign proliferative and sclerosing breast lesions which themselves may show associated sclerosing or 'adenosquamous proliferation' (ASP) resembling LGASC, but are often derided as reactive mimics or attributed to earlier biopsy. Among other benign lesions, radial sclerosing lesion (RSL) may be associated with LGASC, yet attention is typically focused on its relationship to more common forms of mammary carcinoma. This study aimed to assess the presence and extent of ASP in the context of RSL in a small cohort of 20 cases and its similarity to LGASC.
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