Post-exercise intramuscular O supply is tightly coupled with a higher proximal-to-distal ATP synthesis rate in human tibialis anterior.

Key Points: The post-exercise recovery of phosphocreatine, a measure of the oxidative capacity of muscles, as assessed by P MR spectroscopy, shows a striking increase from distal to proximal along the human tibialis anterior muscle. To investigate why this muscle exhibits a greater oxidative capacity proximally, we tested whether the spatial variation in phosphocreatine recovery rate is related to oxygen supply, muscle fibre type or type of exercise. We revealed that oxygen supply also increases from distal to proximal along the tibialis anterior, and that it strongly correlated with phosphocreatine recovery.

3D P MR spectroscopic imaging of the human brain at 3 T with a P receive array: An assessment of H decoupling, T relaxation times, H- P nuclear Overhauser effects and NAD.

P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, P MRSI is currently limited to research purposes. To obtain 3D P MRSI spectra with improved signal-to-noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual-tuned birdcage transmit coil and a P eight-channel phased-array receive insert.

A multitransmit external body array combined with a H and P endorectal coil to enable a multiparametric and multimetabolic MRI examination of the prostate at 7T.

Purpose: In vivo H and P magnetic resonance spectroscopic imaging (MRSI) provide complementary information on the biology of prostate cancer. In this work we demonstrate the feasibility of performing multiparametric imaging (mpMRI) and H and P spectroscopic imaging of the prostate using a P and H endorectal radiofrequency coil (ERC) in combination with a multitransmit body array at 7 Tesla (T).

Methods: An ERC with a P transceiver loop coil and H receive (Rx) asymmetric microstrip ( P/ H ERC) was designed, constructed and tested in combination with an external 8-channel H transceiver body array coil (8CH).

An 8-channel receive array for improved P MRSI of the whole brain at 3T.

Purpose: To demonstrate a H/ P whole human brain volume coil configuration for 3 Tesla with separate P transmit and receive components that maintains H MRS performance and delivers optimal P MRSI with H decoupling.

Methods: We developed an 8-channel P receive array coil covering the head to be used as an insert for a commercial double-tuned H/ P birdcage transmit-receive coil. This retains the possibility of using low-power rectangular pulses for H-decoupled 3D P MRSI (nominal resolution 17.

Oxidative capacity varies along the length of healthy human tibialis anterior.

Key Points: During exercise skeletal muscles use the energy buffer phosphocreatine. The post-exercise recovery of phosphocreatine is a measure of the oxidative capacity of muscles and is traditionally assessed by P magnetic resonance spectroscopy of a large tissue region, assuming homogeneous energy metabolism. To test this assumption, we collected spatially resolved spectra along the length of human tibialis anterior using a home-built array of P detection coils, and observed a striking gradient in the recovery rate of phosphocreatine, decreasing along the proximo-distal axis of the muscle.

Feasibility of Multiparametric Magnetic Resonance Imaging of the Prostate at 7 T.

Objectives: The aim of this study was to evaluate the technical feasibility of prostate multiparametric magnetic resonance imaging (mpMRI) at a magnetic field strength of 7 T.

Materials And Methods: In this prospective institutional review board-approved study, 14 patients with biopsy-proven prostate cancer (mean age, 65.2 years; median prostate-specific antigen [PSA], 6.

Cell tracking using (19)F magnetic resonance imaging: technical aspects and challenges towards clinical applications.

(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.

(31) P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, Nuclear Overhauser Effect, and spectral characterization.

Purpose: Optimization of phosphorus ((31) P) MR spectroscopic imaging (MRSI) of the human prostate at 7 T by the evaluation of T1 relaxation times and the Nuclear Overhauser Effect (NOE) of phosphorus-containing metabolites.

Methods: Twelve patients with prostate cancer and one healthy volunteer were scanned on a 7 T whole-body system using a (31) P endorectal coil combined with an eight-channel (1) H body array coil. T1 relaxation times were measured using progressive saturation in a two-dimensional localization sequence.

Phosphorus magnetic resonance spectroscopic imaging at 7 T in patients with prostate cancer.

Objectives: The aim of this study was to identify characteristics of phosphorus (P) spectra of the human prostate and to investigate changes of individual phospholipid metabolites in prostate cancer through in vivo P magnetic resonance spectroscopic imaging (MRSI) at 7 T.

Materials And Methods: In this institutional review board-approved study, 15 patients with biopsy-proven prostate cancer underwent T2-weighted magnetic resonance imaging and 3-dimensional P MRSI at 7 T. Voxels were selected at the tumor location, in normal-appearing peripheral zone tissue, normal-appearing transition zone tissue, and in the base of the prostate close to the seminal vesicles.

Clinical comparison between a currently available single-loop and an investigational dual-channel endorectal receive coil for prostate magnetic resonance imaging: a feasibility study at 1.5 and 3 T.

Objectives: The objectives of this study were to test the feasibility of an investigational dual-channel next-generation endorectal coil (NG-ERC) in vivo, to quantitatively assess signal-to-noise ratio (SNR), and to get an impression of image quality compared with the current clinically available single-loop endorectal coil (ERC) for prostate magnetic resonance imaging at both 1.5 and 3 T.

Materials And Methods: The study was approved by the institutional review board, and written informed consent was obtained from all patients.

In vivo 31P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility.

(31)P MR spectroscopic imaging of the human prostate provides information about phosphorylated metabolites that could be used for prostate cancer characterization. The sensitivity of a magnetic field strength of 7 T might enable 3D (31)P MR spectroscopic imaging with relevant spatial resolution in a clinically acceptable measurement time. To this end, a (31)P endorectal coil was developed and combined with an eight-channel (1)H body-array coil to relate metabolic information to anatomical location.