Management of Patients With Pancreatic Cysts: Analysis of Possible False-Negative Cases of Malignancy.

Goals: To examine the utility of integrated molecular pathology (IMP) in managing surveillance of pancreatic cysts based on outcomes and analysis of false negatives (FNs) from a previously published cohort (n=492).

Background: In endoscopic ultrasound with fine-needle aspiration (EUS-FNA) of cyst fluid lacking malignant cytology, IMP demonstrated better risk stratification for malignancy at approximately 3 years' follow-up than International Consensus Guideline (Fukuoka) 2012 management recommendations in such cases.

Study: Patient outcomes and clinical features of Fukuoka and IMP FN cases were reviewed.

Integrated molecular pathology accurately determines the malignant potential of pancreatic cysts.

Background And Study Aims: Current diagnostic testing is inadequate to determine the malignant potential of pancreatic cysts, resulting in overcautious patient management. Integrated molecular pathology (IMP) testing combines molecular analysis with first-line test results (cytology, imaging, and fluid chemistry) to assess the malignant potential of pancreatic cysts. This multicenter study aimed to determine the diagnostic accuracy of IMP for pancreatic adenocarcinoma, and the utility of IMP testing under current guideline recommendations for managing pancreatic cysts.

A low-residue diet improved patient satisfaction with split-dose oral sulfate solution without impairing colonic preparation.

Background: Preprocedural dietary restrictions have been identified as a common reason potential candidates for colorectal cancer screening do not undergo colonoscopy as recommended.

Objective: To study whether a low-residue diet impacts bowel preparation with oral sulfate solution.

Design: Endoscopist blinded, prospective, randomized controlled trial.