Publications by authors named "Mark J Becker"
Article Synopsis
- HPV infections cause changes in gene methylation that may drive the development of anal and cervical cancers.
- This study analyzed DNA from anal and cervical tissues to identify specific methylation changes associated with cancer progression.
- The research found common gene methylation patterns between anal and cervical cancer, suggesting similar mechanisms of HPV-driven cancer development, and highlights potential markers for identifying high-risk pre-cancerous lesions.
Purpose: To measure co-expression of EGFR and Ki67 proteins in pretreatment tumor biopsies of anal cancer patients enrolled on NRG Oncology RTOG 9811, a phase III trial comparing 5-fluorouracil/mitomycin-C/radiation therapy (Arm A) versus 5-fluorouracil/cisplatin/radiation therapy (Arm B), and to correlate expression with clinical outcome.
Methods And Materials: EGFR and Ki67 co-expression was measured after constructing a tissue microarray using fluorescence immunohistochemistry and automated quantitative image analysis. The Ki67 score within EGFR high versus low areas (Ki67ratio in EGFR) in each tumor core was analyzed at the median, quartiles, and as a continuous variable.