Publications by authors named "Mark Hyun"
Background: Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).
View Article and Find Full Text PDFArticle Synopsis
- The study compared the effectiveness of silicone photomultipliers (SiPM) and traditional photomultiplier tubes (PMT) in PET imaging for coronary plaque activity using F-sodium fluoride (F-NaF).
- Conducted with 25 cardiovascular patients, the research measured image noise, signal-to-noise ratio (SNR), and target-to-background ratio (TBR) using both PET systems.
- Results demonstrated that SiPM PET provided clearer images with significantly lower noise levels and higher SNR and TBR compared to PMT PET, indicating better performance for coronary imaging.
Background: Despite its potential benefits, the utilization of stress-only protocol in clinical practice has been limited. We report utilizing stress-first single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).
Methods: We assessed 12,472 patients who were referred for SPECT-MPI between 2013 and 2020.
Motion correction (MC) affects myocardial blood flow (MBF) measurements in Rb PET myocardial perfusion imaging (MPI); however, frame-by-frame manual MC of dynamic frames is time-consuming. This study aims to develop an automated MC algorithm for time-activity curves used in compartmental modeling and compare the predictive value of MBF with and without automated MC for significant coronary artery disease (CAD). In total, 565 patients who underwent PET-MPI were considered.
View Article and Find Full Text PDFPurpose: We sought to evaluate inter-scan and inter-reader agreement of coronary calcium (CAC) scores obtained from dedicated, ECG-gated CAC scans (standard CAC scan) and ultra-low-dose, ungated computed tomography attenuation correction (CTAC) scans obtained routinely during cardiac PET/CT imaging.
Methods: From 2928 consecutive patients who underwent same-day Rb cardiac PET/CT and gated CAC scan in the same hybrid PET/CT scanning session, we have randomly selected 200 cases with no history of revascularization. Standard CAC scans and ungated CTAC scans were scored by two readers using quantitative clinical software.
Predictive Model for Rb Generator Bolus Times as a Function of Generator Lifetime.
J Nucl Med Technol
March 2022
Rb cardiac PET is largely used to study myocardial perfusion with function and to calculate myocardial blood flow (MBF) and coronary flow reserve or myocardial flow reserve. Although the dosing activity of Rb is determined by the patient weight, the infusion volume and activity concentration varies with the age of the Rb generator. We sought to predict the needed bolus volume of Rb to help evaluate the accuracy of MBF findings.
View Article and Find Full Text PDFPurpose: Population dose has been a concern with coronary artery calcium scoring CT since it is performed in adults with borderline risk. Lower tube voltage acquisitions are appealing but there are no agreed schemes for reduced dose determination. Moreover, conventional scoring cannot be used without changing the multiple Agatston thresholds.
View Article and Find Full Text PDFIntroduction: Assessment of myocardial uptake of Tc-99m-pyrophosphate (Tc-99m PYP) is pivotal in distinguishing transthyretin-associated cardiac amyloidosis (ATTR) from light chain amyloid (AL). It is often difficult to differentiate myocardial uptake from blood pool radioactivity with planar imaging or SPECT. We studied whether simultaneous dual-isotope Tc-99m PYP/Tl-201 SPECT improves assessment of Tc-99m PYP uptake compared to single-isotope SPECT.
View Article and Find Full Text PDFBackground: We studied the prognostic value of fully automated quantitative analysis software applied to new solid-state, high-speed (HS) SPECT-myocardial perfusion imaging (MPI).
Methods: 1,613 consecutive patients undergoing exercise or adenosine HS-MPI were followed for 2.6 ± 0.
Background: Transient ischemic dilation (TID) of the left ventricle in myocardial perfusion SPECT (MPS) has been shown to be a clinically useful marker of severe coronary artery disease (CAD). However, TID has not been evaluated for 99mTc-sestamibi rest/stress protocols (Mibi-Mibi). We aimed to develop normal limits and evaluate diagnostic power of TID ratio for Mibi-Mibi scans.
View Article and Find Full Text PDFPurpose: We aimed to evaluate the prognostic value of automated quantitative hypoperfusion parameters derived from adenosine stress myocardial perfusion SPECT (MPS) for predicting sudden or cardiac death (CD) in case-controlled patients with suspected coronary artery disease (CAD).
Methods: We considered patients with available adenosine stress Tc-99m sestamibi MPS scans and follow-up information. 81 CD patients from a registry of 428 patients documented by the National Death Index were directly matched in a retrospective case-control design to patients without CD by key clinical parameters (age by deciles, gender, no early revascularization, pre-test likelihood categories, diabetes, and chest pain symptoms).
Background: The clinical usefulness of a rapid rest low-dose/stress high-dose (dose ratio =1:5) (99m)Tc-sestamibi myocardial perfusion single-photon emission computed tomography (SPECT) protocol for the detection of coronary artery disease was evaluated.
Methods And Results: In 89 patients, rest images were obtained immediately after the injection of (99m)Tc-sestamibi (256.1+/-28.