Dynamic imbalances in cell-type specific striatal ensemble activity during visually guided locomotion.

Locomotion is continuously regulated by an animal's position within an environment relative to goals. Direct and indirect pathway striatal output neurons (dSPNs and iSPNs) influence locomotion, but how their activity is naturally coordinated by changing environments is unknown. We found, in head-fixed mice, that the relative balance of dSPN and iSPN activity was dynamically modulated with respect to position within a visually-guided locomotor trajectory to retrieve reward.

Spatially organized striatal neuromodulator release encodes trajectory errors.

Goal-directed navigation requires animals to continuously evaluate their current direction and speed of travel relative to landmarks to discern whether they are approaching or deviating from their goal. Striatal dopamine and acetylcholine are powerful modulators of goal-directed behavior, but it is unclear whether and how neuromodulator dynamics at landmarks incorporate relative motion for effective behavioral guidance. Using optical measurements in mice, we demonstrate that cue-evoked striatal dopamine release encodes bi-directional 'trajectory errors' reflecting relationships between ongoing speed and direction of locomotion and visual flow relative to optimal goal trajectories.

Spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian cues and actions.

Striatal acetylcholine (ACh) has been linked to behavioral flexibility. A key component of flexibility is down-regulating responding as valued cues and actions become decoupled from positive outcomes. We used array fiber photometry in mice to investigate how ACh release across the striatum evolves during learning and extinction of Pavlovian associations.

True and false memory priming of perceptual closure problems in healthy older adults and older adults with Alzheimer's disease.

Objective: The present study set out to investigate whether false memories for pictures exhibit priming effects in older adult controls (OACs) and people with early onset Alzheimer's disease (AD). We conducted two studies to examine whether false memories for pictures had a priming effect on a perceptual closure task (PCT).

Method: In Experiment 1, OACs and people with early onset AD were presented with pictorial versions of the Deese/Rodiger-McDermott lists and took part in a recognition task.

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior.

Neural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally occurring patterns of large-scale, distributed dynamics within and across deep brain regions such as the striatum. We designed a new micro-fiber array approach capable of chronically measuring and optogenetically manipulating local dynamics across over 100 targeted locations simultaneously in head-fixed and freely moving mice, enabling the investigation of cell-type- and neurotransmitter-specific signals over arbitrary 3D volumes at a spatial resolution and coverage previously inaccessible.

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior.

Neural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally occurring patterns of large-scale, distributed dynamics within and across deep brain regions such as the striatum. We designed a new micro-fiber array and imaging approach capable of chronically measuring and optogenetically manipulating local dynamics across over 100 targeted locations simultaneously in head-fixed and freely moving mice.

External and internal influences yield similar memory effects: the role of deception and suggestion.

In legal cases, testimonies can become contaminated because of an amalgam of external and internal influences on memory. It is well-established that external influences (e.g.

Creating false rewarding memories guides novel decision making.

When memories of past rewarding experiences are distorted, are relevant decision-making preferences impacted? Although recent research has demonstrated the important role of episodic memory in value-based decision making, very few have examined the role of false memory in guiding novel decision making. The current study combined the pictorial Deese/Roediger-McDermott false memory paradigm with a reward learning task, where participants learned that items from some related lists gained reward and items from other lists led to no reward. Later, participants' memories and decision-making preferences were tested.

Early Childhood Memories Are not Repressed: Either They Were Never Formed or Were Quickly Forgotten.

Early childhood events are rarely remembered in adulthood. In fact, memory for these early experiences declines during childhood itself. This holds regardless of whether these memories of autobiographical experiences are traumatic or mundane, everyday experiences.

Oversimplifications and Misrepresentations in the Repressed Memory Debate: A Reply to Ross.

Ross argued that false memory researchers misunderstand the concepts of repression and dissociation, as well as the writings of Freud. In this commentary, we show that Ross is wrong. He oversimplifies and misrepresents the literature on repressed and false memory.

Generative processing and emotional false memories: a generation "cost" for negative false memory formation but only after delay.

Previous research shows that manipulations (e.g. levels-of-processing) that facilitate true memory often increase susceptibility to false memory.

Memory construction: a brief and selective history.

In this short article, we provide a brief introduction to the idea that memory involves constructive processes. The importance of constructive processes in memory has a rich history, one that stretches back more than 125 years. This historical context provides a backdrop for the articles appearing in this special issue of Memory, articles that outline the current thinking about the constructive nature of memory.

Self-Enhanced False Memory Across the Life Span.

Objectives: The role of self in veridical memory has been extensively studied, but what is the role of self in false memory development across the life span? The current study examined the impact of self-reference on associative false memory in children, younger adults, and older adults, and further investigated possible mechanisms concerning how self-reference might affect false memory in different age groups.

Methods: Combining a self-reference manipulation with the Deese/Roediger-McDermott (DRM) paradigm, children, younger adults, and older adults encoded DRM word lists as paired with their own name, another person's name, or a red square. Later their true and false recognition memory as well as recollection and familiarity were measured.

Manipulating Memory Associations Minimizes Avoidance Behavior.

Memories of the past can guide humans to avoid harm. The logical consequence of this is if memories are changed, avoidance behavior should be affected. More than 80 years of false memory research has shown that people's memory can be re-constructed or distorted by receiving suggestive false feedback.

Self-referential false associations: A self-enhanced constructive effect for verbal but not pictorial stimuli.

Memory is considered to be a flexible and reconstructive system. However, there is little experimental evidence demonstrating how associations are falsely constructed in memory, and even less is known about the role of the self in memory construction. We investigated whether false associations involving non-presented stimuli can be constructed in episodic memory and whether the self plays a role in such memory construction.

Belief in Unconscious Repressed Memory Persists.

On the basis of converging research, we concluded that the controversial topic of unconscious blockage of psychological trauma (i.e., repressed memory) remains very much alive in clinical, legal, and academic contexts.

What science tells us about false and repressed memories.

What does science tell us about memory phenomena such as false and repressed memories? This issue is highly pressing as incorrect knowledge about these memory phenomena might contribute to egregious effects in the courtroom such as false accusations of abuse. In the current article, we provide a succinct review of the scientific nature of false and repressed memories. We demonstrate that research has shown that about 30% of tested subjects formed false memories of autobiographical experiences.

Skirting the issue: What does believing in repression mean?

We show that, in contrast to Brewin, Li, Ntarantana, Unsowrth, and McNeilis (2019), large proportions of laypersons believe in the scientifically controversial phenomenon of unconscious repressed memories. We provide new survey data showing that when participants are asked specific questions about what they mean when they report that traumatic memories can be repressed, most provide answers strongly consistent with unconscious repression. Our findings continue to show that researchers, legal professionals, and clinicians should be wary of invoking unconscious repression in their work.