Publications by authors named "Mark He"

Background: Following the adoption of new nomenclature for steatotic liver disease, we aimed to build consensus on the use of International Classification of Diseases codes and recommendations for future research and advocacy.

Methods: Through a two-stage Delphi process, a core group (n = 20) reviewed draft statements and recommendations (n = 6), indicating levels of agreement. Following revisions, this process was repeated with a large expert panel (n = 243) from 73 countries.

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Background And Aims: Fatty liver disease is highly prevalent, resulting in overarching wellbeing and economic costs. Addressing it requires comprehensive and coordinated multisectoral action. We developed a fatty liver disease Sustainable Development Goal (SDG) country score to provide insights into country-level preparedness to address fatty liver disease through a whole-of-society lens.

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Background And Aims: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care.

Approach And Results: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice.

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Background & Aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community.

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Article Synopsis
  • Non-invasive tests (NITs) are increasingly utilized for identifying advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), but their inconsistent use leads to varied interpretations.
  • * A survey of liver health experts from around the world revealed that many use different types of NITs, with most favoring FIB-4 and Fibroscan for assessments, but significant variations exist in the cut-off values they're using.
  • * Findings highlight the need for standardized guidelines to improve risk assessment consistency and enhance patient management in NAFLD, given the potential impact of varying cut-off values on test accuracy.
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Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely underappreciated liver condition which is closely associated with obesity and metabolic disease. Despite affecting an estimated 1 in 4 adults globally, NAFLD is largely absent on national and global health agendas.

Methods: We collected data from 102 countries, accounting for 86% of the world population, on NAFLD policies, guidelines, civil society engagement, clinical management, and epidemiologic data.

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Background: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition that requires a comprehensive and coordinated response across sectors and disciplines.

Aims: In the absence of a multisectoral framework to tackle this condition, we developed one using the sustainable development goals (SDGs) as the basis for converging thinking about the design and delivery of public health responses.

Methods: A multidisciplinary group identified the SDG targets and indicators for inclusion in the new framework through a two-stage process.

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Article Synopsis
  • * NAFLD is part of a broader metabolic syndrome, yet it remains mostly unknown outside of specialized medical fields, with inadequate public health responses and a lack of inclusion in national health strategies.
  • * A global Delphi study involving experts generated consensus statements and recommendations on various aspects of NAFLD, aiming to improve awareness, treatment, and public health policies, providing a valuable resource for stakeholders involved in addressing the disease.
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  • * A systematic literature search revealed seven care models and provided insights into the services offered, their locations, the providers, and the coordination of care.
  • * Eight recommendations were developed for policymakers and healthcare practitioners to enhance care for NAFLD patients, based on effective practices identified in the models.
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Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions worldwide. Collectively, Latin American countries have some of the highest obesity rates in the world and the fastest-growing prevalence of type 2 diabetes mellitus (T2DM). Since obesity and T2DM are intrinsically linked with NAFLD, epidemiological projections are worrisome.

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Healthy diets are a human right and the foundation of just, resilient societies

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We develop a method to identify statistically significant communities in a weighted network with a high proportion of self-looping weights. We use this method to find overlapping agglomerations of U.S.

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  • Cameroon has mandated the fortification of vegetable oil with vitamin A and wheat flour with various micronutrients since 2011, but initial levels of fortification have not met the targets, particularly for oil.
  • A study used a program impact pathway to analyze barriers to effective food fortification, conducting interviews with factories and assessing food availability and consumption among households.
  • Results showed that while some factories maintained quality standards, actual micronutrient levels in fortified foods were often well below targets, indicating room for improvement in the program's effectiveness.
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The F-AV-1451 PET tracer binds to tau, an Alzheimer's disease biomarker. The standardized uptake value ratio (SUVR) 80-100 min window is widely used to quantify tau binding, although F-AV-1451 continues increasing relative to a reference region in regions with tau deposition. Left uncorrected, acquisition time inaccuracies can lead to errors from -4% to 6% in 20-min SUVR measurements in subjects with Alzheimer's disease.

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Unlabelled: The goal of this paper was to evaluate the in vivo kinetics of the novel tau-specific PET radioligand F-AV-1451 in cognitively healthy control (HC) and Alzheimer disease (AD) subjects, using reference region analyses.

Methods: F-AV-1451 PET imaging was performed on 43 subjects (5 young HCs, 23 older HCs, and 15 AD subjects). Data were collected from 0 to 150 min after injection, with a break from 100 to 120 min.

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Article Synopsis
  • - Micronutrient deficiencies are a significant global health issue, especially in South Asia, where many countries face high levels of inadequacy for essential nutrients.
  • - A study assessed the prevalence of deficiencies in seven micronutrients (like vitamin A, B-12, zinc, and calcium) across seven South Asian countries and found that lower-income nations are particularly affected, with calcium being the most at risk.
  • - To effectively address these deficiencies and implement nutritional programs, there's an urgent need for nationwide surveys to collect reliable data on the actual state of micronutrient malnutrition in these countries.
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26 patients hospitalized with Hyperemesis Gravidarum were treated with electrical stimulation of the vestibular system, as the symptoms of Hyperemesis Gravidarum resemble the symptoms of motion sickness, where the electrical stimulation has been used successfully. The patients were treated for one hour daily, two hours before the standard infusion therapy. 89% reported a decrease in vomiting and nausea during the first application, 85% a lasting improvement.

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