Publications by authors named "Mark Hardink"
Atropisomerism can be a complex concept for those who have not encountered it before. This paper discusses the experiments for identification, isolation, thermal stability, toxicity and biotransformation of various species. The identified atropisomers are a series of rotational hindered biaryl, rotational hindered amide, ring flip, and macrocycles atropisomers identified using supercritical fluid chromatography (SFC) and high performance liquid chromatography (HPLC).
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- Polysaccharide-derived selectors are utilized in supercritical fluid chromatography (SFC) to separate enantiomers, primarily tested with alcohols and acetonitrile.
- The study conducted by Pfizer and Chiral Technologies Inc. evaluated the effectiveness of alternative solvents like ethyl acetate and tetrahydrofuran alongside various polysaccharide-derived supports.
- Results indicated that using a broader range of solvents improved success rates and helped address issues like racemization and solubility when analyzing standard and research samples.
Article Synopsis
- DBU effectively catalyzes the amidation of acyl imidazoles, enhancing the reaction rates, especially with less reactive, electron-deficient anilines.
- It is more accessible and safer, presenting cost benefits compared to traditional catalysts like 1-hydroxybenzotriazole.
- This makes DBU a valuable alternative for organic synthesis in the lab.
Carbonyldiimidazole (CDI) was found to mediate the Lossen rearrangement of various hydroxamic acids to isocyanates. This process is experimentally simple and mild, with imidazole and CO(2) being the sole stoichiometric byproduct. Significant for large-scale application, the method avoids the use of hazardous reagents and thus represents a green alternative to standard processing conditions for the Curtius and Hofmann rearrangements.
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