Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease.

Background: Mycobacterium ulcerans (M. ulcerans) causes a devastating necrotising infection of skin tissue leading to progressive ulceration. M.

Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.

Background: Mycobacterium ulcerans disease (Buruli ulcer) is a neglected tropical disease common amongst children in rural West Africa. Animal experiments have shown that tissue destruction is caused by a toxin called mycolactone.

Methodology/principal Findings: A molecule was identified among acetone-soluble lipid extracts from M.

Mycobacterium ulcerans disease.

Mycobacterium ulcerans disease (Buruli ulcer) is an important health problem in several west African countries. It is prevalent in scattered foci around the world, predominantly in riverine areas with a humid, hot climate. We review the epidemiology, bacteriology, transmission, immunology, pathology, diagnosis and treatment of infections.

Emerging aspects of Buruli ulcer.

Buruli ulcer, caused by the pathogen Mycobacterium ulcerans, is a major mycobacteriosis that affects people in scattered foci in the third world. It is amongst the most neglected of diseases in terms of primary healthcare strategies. However, this is changing as the World Health Organization launches a number of major global initiatives.

Buruli ulcer.

Buruli ulcer (Mycobacterium ulcerans) is an emerging disease. The mode of transmission is still unknown. Mycobacterium ulcerans has been detected (by polymerase chain reaction) in water and water insects.