Early assessment of recurrent glioblastoma response to bevacizumab treatment by diffusional kurtosis imaging: a preliminary report.

Purpose: The purpose of this preliminary study is to apply diffusional kurtosis imaging to assess the early response of recurrent glioblastoma to bevacizumab treatment.

Methods: This prospective cohort study included 10 patients who had been diagnosed with recurrent glioblastoma and scheduled to receive bevacizumab treatment. Diffusional kurtosis images were obtained from all the patients 0-7 days before (pre-bevacizumab) and 28 days after (post-bevacizumab) initiating bevacizumab treatment.

Vessel target location estimation during the TIPS procedure.

Creation of a transjugular intrahepatic portosystemic shunt (TIPS) requires passage of a needle toward a moving target that is only seen transiently by X-ray prior to needle passage. Intraoperative, 3D target localization would facilitate target access and improve the safety of the procedure. The clinical assumption is that patients undergoing the TIPS procedure possess rigid, cirrhotic livers that undergo only intraoperative translation without significant deformation or rotation.

3D stereo interactive medical visualization.

Transjugular intrahepatic portosystemic shunt formation (TIPS) is an effective treatment for portal hypertension [LaBerge 1995]. The procedure requires the insertion of a needle through the liver to connect the hepatic and portal veins. This operation is traditionally guided by fluoroscopic images that do not show the location of the target veins during needle insertion.