Publications by authors named "Mark G Hausmann"
The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [n = 5] or sleeve gastrectomy [n = 7]) or LCD (n = 7) in this parallel-arm, prospective observational study.
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- The study explores adipose-derived stromal/stem cells (ASC) as a valuable resource for tissue engineering, comparing cells isolated from omental (abdominal) and subcutaneous (under the skin) fat.
- Human tissue samples were obtained with consent from surgical patients, and ASC were cultured and differentiated into fat or bone cells.
- While omental and subcutaneous ASC had similar yields and initial characteristics, omental ASC showed significantly lower capacity to differentiate into adipogenic cells, indicating they are not interchangeable for regenerative medicine purposes.
The aim of this study was to assess prospectively 2-year outcomes of transoral incisionless fundoplication (TIF) in a multicenter setting. A 14-center U.S.
View Article and Find Full Text PDFBackground: Preoperative factors predicting symptomatic improvement after transoral fundoplication (TF) in chronic gastroesophageal reflux disease (GERD) patients with persistent symptoms on proton-pump inhibitors (PPIs) therapy have not been elucidated fully.
Methods: Univariate and multivariate logistic regression analyses were performed on data from 158 consecutive patients who underwent TF with the EsophyX device between January 2010 and June 2012 in 14 community centers. Variables included age, gender, body mass index, GERD duration, PPIs therapy duration, presence of hiatal hernia, esophagitis, Hill grade, quality of life scores (QOL) on PPIs, % total time pH < 4, and DeMeester score on reflux testing off PPIs.
The effects of transoral incisionless fundoplication on chronic GERD patients: 12-month prospective multicenter experience.
Surg Laparosc Endosc Percutan Tech
February 2014
Article Synopsis
- * No major complications were found, with significant reductions in the need for proton pump inhibitors and improvements in symptoms like heartburn and regurgitation among patients.
- * Overall, TIF was concluded to be a safe and effective treatment option for selected patients suffering from chronic GERD.
Article Synopsis
- Laparoscopic sleeve gastrectomy is a popular weight-loss surgery for morbidly obese patients, showing significant short- to mid-term weight loss results.
- A review of the first 100 patients indicated 34.2% weight loss at 3 months and 49.1% at 6 months, with notable improvements in comorbidities and a 10% complication rate.
- The study concludes that the technique is safe, effective, and does not require modifications, making it a strong surgical option for obesity management.
Article Synopsis
- GERD is common in obese patients, and while Roux-en-Y gastric bypass improves symptoms, the impact of laparoscopic sleeve gastrectomy (LSG) on GERD is less understood.* -
- A study of 176 LSG patients showed that 34.6% had GERD before surgery, but 49% reported new or worsened GERD symptoms shortly after, with 47.2% experiencing persistent symptoms after one month.* -
- Overall, LSG did not alleviate GERD for those who had it preoperatively, and even those without prior GERD faced increased risks of developing symptoms post-surgery.*
This is the first documented case in North America wherein a 26-year-old man presented to the emergency room with hemoperitoneum secondary to avulsed short gastric arteries after violent emesis.
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