The Value of Researcher Reflexivity in the Coproduction of Public Policy: A Practical Perspective.

Coproduction of public policy involves bringing together technical experts, practitioners, and people with lived experience of that policy to collaboratively and deliberatively codesign it. Coproduction can leverage different ways of knowing and evaluative perspectives on a policy area to enhance the legitimacy and efficaciousness of policymaking. This article argues that researcher reflexivity is crucial for getting the most out of coproduction ethically and epistemically.

A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging.

Intracranial aneurysms are common, but only a minority rupture and cause subarachnoid haemorrhage, presenting a dilemma regarding which to treat. Vessel wall imaging (VWI) is a contrast-enhanced magnetic resonance imaging (MRI) technique used to identify unstable aneurysms. The pathological basis of MR enhancement of aneurysms is the subject of debate.

causing vertebral osteomyelitis in an immunocompetent patient: a case report and literature review.

vertebral osteomyelitis causing deformity in immunocompetent patients is uncommon. We describe a previously healthy 68-year-old male who was referred after 2 years of lower thoracic back pain and gibbus. His inflammatory markers and HIV test were normal.

Subjective well-being during the 2020-21 global coronavirus pandemic: Evidence from high frequency time series data.

We investigate how subjective well-being varied over the course of the global COVID-19 pandemic, with a special attention to periods of lockdown. We use weekly data from YouGov's Great Britain Mood Tracker Poll, and daily reports from Google Trends, that cover the entire period from six months before until eighteen months after the global spread of COVID-19. Descriptive trends and time-series models suggest that negative mood associated with the imposition of lockdowns returned to baseline within 1-3 weeks of lockdown implementation, whereas pandemic intensity, measured by the rate of fatalities from COVID-19 infection, was persistently associated with depressed affect.

Scale Norming Undermines the Use of Life Satisfaction Scale Data for Welfare Analysis.

Scale norming is where respondents use qualitatively different scales to answer the same question across survey waves. It makes responses challenging to compare intertemporally or interpersonally. This paper develops a formal model of the cognitive process that could give rise to scale norming in year on year responses to life satisfaction scale questions.

Be Happy: Navigating Normative Issues in Behavioral and Well-Being Public Policy.

Psychological science is increasingly influencing public policy. Behavioral public policy (BPP) was a milestone in this regard because it influenced many areas of policy in a general way. Well-being public policy (WPP) is emerging as a second domain of psychological science with general applicability.

Spinal anaplastic ganglioglioma.

Anaplastic gangliogliomas of the spinal cord are extremely rare with only four cases reported in the literature. Here we present the case of a 22-year-old female who presented acutely with quadraparesis and urinary retention. Radiographic imaging demonstrated an intramedullary lesion within the cervical spine.

Intracranial Masson Lesion Following Stereotactic Radiosurgery for Treatment of Intracranial Arteriovenous Malformations.

Objectives: Masson tumor or intravascular papillary endothelial cell proliferation was first described in 1923. Only a few cases of intracranial Masson tumor have been reported following stereotactic radiosurgery (SRS). We report a series of 6 cases, age range 28-56 years, with intracranial Masson tumor following SRS for treatment of an intracranial arteriovenous malformation (AVM).

Novel compounds with potent CDK9 inhibitory activity for the treatment of myeloma.

Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor.

Bioretention column study of bacteria community response to salt-enriched artificial stormwater.

Cold climate cities with green infrastructure depend on soil bacteria to remove nutrients from road salt-enriched stormwater. Our research examined how bacterial communities in laboratory columns containing bioretention media responded to varying concentrations of salt exposure from artificial stormwater and the effect of bacteria and salt on column effluent concentrations. We used a factorial design with two bacteria treatments (sterile, nonsterile) and three salt concentrations (935, 315, and 80 ppm), including a deionized water control.