Publications by authors named "Mark F M van Doremalen"
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Synopsis of recent research by authors named "Mark F M van Doremalen"
- Mark F M van Doremalen's recent research focuses on the synthesis of nisin AB dicarba analogs, exploring how varying the hybridization of α-carbon atoms in specific amino acid residues affects their biochemical properties.
- The study specifically examines the influence of sp(3) versus sp(2) hybridization in residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity of these nisin analogs, which are of interest for their antimicrobial properties.
- Utilizing advanced synthetic techniques, including solid-phase synthesis and ring-closing metathesis, the research contributes to the understanding of how modifications in peptide structure can enhance or alter function, particularly in microbial inhibition contexts.
