Publications by authors named "Mark E Mayes"
Regul Toxicol Pharmacol
June 2011
Article Synopsis
- In 1998, the National Toxicology Program found that tetrahydrofuran exposure led to increased kidney tumors in male rats and liver tumors in female mice.
- A new evaluation using the IPCS/ILSI Framework sought to identify the mode(s) of action behind the kidney tumors in rats and their relevance to human health.
- The analysis suggested that kidney tumors in rats were mainly due to chronic progressive nephropathy rather than direct carcinogenic effects, indicating that these findings are not applicable for human risk assessments.
