Publications by authors named "Mark David Francisco"
Article Synopsis
- Sulfonylureas (SUs), like gliclazide and glimepiride, are commonly used medications for managing type 2 diabetes in the Philippines, and the study aimed to explore the genetic factors affecting their effectiveness.
- The research involved 252 participants across two studies, where genetic testing was conducted to identify associations between genetic variants and the individual responses to these medications.
- Results showed that certain genetic variants were significantly linked to poor responses to gliclazide and glimepiride, suggesting that understanding these genetic factors could improve treatment strategies for diabetes in the Filipino population.
Diabetes mellitus (DM) is a known risk factor for morbidity and mortality among patients with COVID-19 based on recent studies. While there are many local and international guidelines on inpatient management of diabetes, the complicated pathology of the virus, the use of glucose-elevating drugs such as glucocorticoids, antivirals and even inotropes, and various other unique problems has made the management of in-hospital hyperglycemia among patients with COVID-19 much more difficult than in other infections. The objective of this guidance is to collate and integrate the best available evidence that has been published regarding in-patient management of diabetes among patients with COVID-19.
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