Publications by authors named "Mark Daubaras"
Article Synopsis
- The study reveals that Rab13, a small GTPase, plays a crucial role in the transport of vesicles in epithelial cells, linked to cancer progression.
- Researchers identified DENND2B as the protein that activates Rab13, using a new biosensor to visualize this activation during cell movement.
- The interaction between DENND2B and another protein, MICAL-L2, is essential for cell behavior, and inhibiting Rab13 could be a potential strategy to reduce the spread of epithelial cancers.
Pseudomonas aeruginosa type IV pili (T4P) are virulence factors that promote infection of cystic fibrosis and immunosuppressed patients. As the absence of T4P impairs colonization, they are attractive targets for the development of novel therapeutics. Genes in the pilMNOPQ operon are important for both T4P assembly and a form of bacterial movement, called twitching motility, that is required for pathogenicity.
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