Apparent texture symmetry deviations in aluminum sheet.

An ultrasonic texture measurement system for sheet metal is being developed using rotating electromagnetic acoustic transducers (EMATs). We report on further investigations of deviation from theoretically predicted symmetries in the elastic constants (as measured ultrasonically using the aforementioned system) of cold-rolled aluminum sheet reported in earlier publications. A study of the effects of annealing and deliberate deformation (both elastic and plastic) are used to develop an explanation of the nature and likely origin of this asymmetry.

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.

Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locus in mouse chromosome 7 cause hematopoietic abnormalities, growth retardation, and shortened life span, with varying severity of the defects in different alleles. Abnormal iron distribution and metabolism and frequent scoliosis have also been associated with an allele of intermediate severity (fit14R). We report that fit14R, as well as the most severe fit15R allele, are nonsense point mutations in the mouse ortholog of the human phosphatidylinositol-binding clathrin assembly protein (PICALM) gene, whose product is involved in clathrin-mediated endocytosis.