Publications by authors named "Mark Conti"
JCI Insight
November 2019
Article Synopsis
- Elevated arginase 1 activity leads to a depletion of extracellular arginine, which negatively impacts T cell function and serves as an immunosuppressive mechanism in tumors.
- The mitochondrial arginase isoform Arg2, expressed in T cells, plays a critical role in regulating CD8+ T cell activity and enhancing their tumor-fighting abilities.
- Deleting Arg2 in CD8+ T cells enhances their activation and effectiveness against tumors, especially when combined with PD-1 blockade, suggesting that targeting Arg2 could be a promising strategy for improving cancer immunotherapy.
