Publications by authors named "Mark Berneburg"

Article Synopsis
  • Granuloma annulare (GA) is a non-infectious skin condition that can become widespread in some patients; this study focused on those with disseminated GA in a German hospital.
  • A total of 239 patients were studied, with 33 having confirmed disseminated GA, predominantly affecting women around the age of 57, and many reporting little to no symptoms.
  • Treatment options included glucocorticoids and phototherapy, but only a small percentage achieved remission, highlighting the need for more effective clinical trials for new therapies.
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With regard to excision of pigmented lesions for detection of malignant melanoma (MM), the number needed to treat (NNT) describes the number of melanocytic nevi that need to be biopsied/excised to detect one MM. The aim should be a low NNT. : Single-center data analysis, including dermatohistopathological records of all nevi and MM cases during 2004-2013 at the Department of Dermatology, University Hospital Regensburg (UKR), was performed.

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We report on two cases of nail tumors associated with onychorrhexis, distal V‑shaped onycholysis, and subungual keratosis. Surgical exposure was performed in each case to confirm the diagnosis. Histopathological examination revealed skin changes consistent with onychopapilloma.

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Actinic keratosis (AK) is characterized by a reddish or occasionally skin-toned rough patch on sun-damaged skin, and it is regarded as a precursor to squamous cell carcinoma (SCC). Photodynamic therapy (PDT), utilizing 5-aminolevulinic acid (ALA) along with red light, is a recognized treatment option for AK that is limited by the penetration depth of light and the distribution of the photosensitizer into the skin. Cold atmospheric plasma (CAP) is a partially ionized gas with permeability-enhancing and anti-cancer properties.

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Cold atmospheric plasma (CAP) devices generate reactive oxygen and nitrogen species, have antimicrobial and antiviral properties, but also affect the molecular and cellular mechanisms of eukaryotic cells. The aim of this study is to investigate CAP treatment in the upper respiratory tract (URT) to reduce the incidence of ventilator-associated bacterial pneumonia (especially superinfections with multi-resistant pathogens) or viral infections (e.g.

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(1) Background: Rare skin cancers include epithelial, neuroendocrine, and hematopoietic neoplasias as well as cutaneous sarcomas. Ultraviolet (UV) radiation and sunburns are important drivers for the incidence of certain cutaneous sarcomas; however, the pathogenetic role of UV light is less clear in rare skin cancers compared to keratinocyte cancer and melanoma. In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV exposure among selected rare skin cancers (atypical fibroxanthoma [AFX], pleomorphic dermal sarcoma [PDS], dermatofibrosarcoma protuberans [DFSP], Kaposi sarcoma [KS], Merkel cell carcinoma [MCC], and leiomyosarcoma [LMS]) while taking into account relevant clinical variables (age, sex, and body site).

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Article Synopsis
  • Voriconazole (VOR), an anti-fungal drug, can cause phototoxicity and skin cancer by impairing the DNA repair process known as nucleotide excision repair (NER).
  • VOR affects NER not by changing the expression of related genes but by binding to heterochromatin, disrupting the acetylation of histone H3, which is necessary for effective DNA repair.
  • Using histone deacetylase inhibitors to restore H3 acetylation can reverse the NER inhibition caused by VOR, suggesting a potential therapeutic strategy to prevent its harmful effects.
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We have recently shown that cancer cells of various origins take up extracellular citrate through the plasma membrane citrate carrier (pmCiC), a specific plasma membrane citrate transporter. Extracellular citrate is required to support cancer cell metabolism, in particular fatty acid synthesis, mitochondrial activity, protein synthesis and histone acetylation. In addition, cancer cells tend to acquire a metastatic phenotype in the presence of extracellular citrate.

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Background And Objectives: Inflammation is a key pathomechanism for growth and rupture of intracranial aneurysms. Anti-inflammatory mechanisms may reduce rupture of intracranial aneurysms and the incidence of aneurysmal subarachnoid hemorrhage (SAH). Ultraviolet (UV) radiation from sunlight exposure induces systemic anti-inflammatory responses through immunosuppressive mechanisms.

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  • Photosensitivity in lupus erythematosus leads to heightened inflammation from sunlight, affecting both skin (cutaneous lupus) and systemic health (systemic lupus).
  • UV radiation can trigger skin damage in cutaneous lupus, causing both temporary and permanent changes, while in systemic lupus, it may worsen the overall condition.
  • Understanding the mechanisms behind UV-induced immune responses is essential for creating strategies to prevent or mitigate the harmful effects of photosensitivity, as the only current prevention method is to avoid UV exposure.
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  • Keratosis palmoplantaris striata type I (SPPK-I) is a rare genetic skin condition marked by painful, thickened areas on palms and soles, often due to mutations in the desmoglein-1 gene.
  • Patients experience hyperkeratotic plaques and painful fissures, but existing treatments like salicylic vaseline and corticosteroids do not provide effective relief.
  • A case study highlights a specific genetic variant linked to SPPK-I, yet the search for effective treatments continues due to the limited options available for this disorder.*
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Background: In melanoma treatment, complete lymph node dissection (CLND) has been considered the therapeutic gold standard in patients with positive sentinel lymph node biopsy (SLNB). This long-held approach was revised in 2017, with recent evidence questioning the therapeutic benefit of CLND in malignant melanoma (MM) therapy. In this study, we aimed to fill this knowledge gap by retrospectively analyzing the impact of CLND on MM patients' survival.

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The link between mitochondria and major depressive disorder (MDD) is increasingly evident, underscored both by mitochondria's involvement in many mechanisms identified in depression and the high prevalence of MDD in individuals with mitochondrial disorders. Mitochondrial functions and energy metabolism are increasingly considered to be involved in MDD's pathogenesis. This study focused on cellular and mitochondrial (dys)function in two atypical cases: an antidepressant non-responding MDD patient ("Non-R") and another with an unexplained mitochondrial disorder ("Mito").

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(1) Background: Ultraviolet (UV) radiation and sunburns are associated with an increased incidence of acquired nevi and melanomas. However, the data are controversial as to whether chronic UV exposure or high intermittent UV exposure is the major carcinogenic factor in melanocytic tumors. In this study, we compared the degree of actinic elastosis (AE) as a surrogate for lifetime UV exposure in nevi and different clinical melanoma subtypes (i.

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Background: People with complex symptomatology but unclear diagnosis presenting to a centre for rare diseases (CRD) may present with mental (co-)morbidity. We hypothesised that combining an expert in somatic medicine with a mental health specialist working in tandem will improve the diagnostic outcome.

Methods: Patients aged 12 years and older who presented to one of the 11 participating German CRDs with an unknown diagnosis were recruited into this prospective cohort trial with a two-phase cohort design.

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Progeroid syndromes (PSs) are characterized by the premature onset of age-related pathologies. PSs display a wide range of heterogeneous pathological symptoms that also manifest during natural aging, including vision and hearing loss, atrophy, hair loss, progressive neurodegeneration, and cardiovascular defects. Recent advances in molecular pathology have led to a better understanding of the underlying mechanisms of these diseases.

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Article Synopsis
  • Despite the rise of effective biologic treatments for skin diseases, UV therapy remains a key part of treatment guidelines due to its effectiveness and low side effects.
  • Phototherapy, including UVA and UVB usage with psoralen in PUVA therapy, is versatile and can treat various conditions like psoriasis, atopic dermatitis, and vitiligo.
  • The article explores how phototherapy works, its mechanisms, and its application in treating different skin diseases.
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A 16-year-old female patient with previously diagnosed acne vulgaris was transferred to our clinic in reduced general condition with rapidly progressive and extremely painful ulcerations. In the laboratory exam, inflammatory parameters were highly elevated, but she was normothermic. Based on the findings, we diagnosed multilocular pyoderma gangrenosum.

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Article Synopsis
  • The increase in people with tattoos has led to a rise in adverse skin reactions, primarily due to unidentified substances in tattoo colorants that can cause allergies or granulomatous reactions.
  • A study involving ten patients with adverse reactions included skin biopsies and extensive testing of tattoo colorants using various scientific methods to identify the triggers of these skin issues.
  • Results showed varied skin reactions linked mainly to red tattoos, and while some substances in the colorants were identified, treatments such as topical steroids proved effective for seven patients in achieving remission from their symptoms.
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Carcinoma erysipelatoides (CE) is a rare clinical manifestation of cutaneous metastasis, which mimics inflammatory conditions such as erysipelas. Depending on the site of the originating tumour, unusual manifestations involving different sites of the body may occur. We herein report a case of a 60-year-old female patient with metastatic endometrial carcinoma presenting as CE of the abdominal skin and the inguinal folds.

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