Publications by authors named "Mark Bachmeier"
Nucleic Acids Res
July 2015
Article Synopsis
- Short contiguous peptide minimotifs can impact human variation and are influenced by selection, often showing a high level of conservation with 94% invariance.
- Analysis of approximately 300,000 minimotifs in nearly 1,100 human genomes revealed that most minimotifs are under negative selection, with some experiencing neutral drift or positive selection similar to coding regions.
- The study suggests minimotifs contribute to genetic variation, potentially affect DNA packaging due to variations in histone tails, and indicate adaptive evolution across different human populations.
