Importance: Mindfulness curricula can improve physician burnout, but implementation during residency presents challenges.
Objective: To examine whether a novel mindfulness curriculum implemented in the first 6 months of internship reduces burnout.
Design, Setting, And Participants: This pragmatic, multicenter, stratified cluster randomized clinical trial of a mindfulness curriculum randomized 340 pediatric interns to the intervention or control arm within program pairs generated based on program size and region.