Approach to Kidney Biopsy: Core Curriculum 2022.

The kidney biopsy is an essential tool for diagnosis of many kidney diseases. Obtaining an adequate biopsy sample with appropriate allocation for various studies is essential. Nephrologists should understand key lesions and their interpretation because these are essential elements underlying optimal approaches for interventions.

Hereditary Nephritis and Thin Glomerular Basement Membrane Lesion.

Hereditary nephritis (HN) and thin glomerular basement membrane (GBM) lesion share a common clinical presentation of persistent hematuria, thin GBM by kidney biopsy electron microscopic examination, and a mutation in type IV collagen. However, the clinical course and treatment for these entities are different with varying patterns of heredity. Ultrastructural examination of a renal biopsy specimen is essential for the morphologic diagnosis of HN and thin GBM lesion, whereas light microscopy may only give limited diagnostic clues.

Educational Case: AA Amyloidosis Complicating Common Variable Immunodeficiency.

http://journals.sagepub.com/doi/10.

AKI and Collapsing Glomerulopathy Associated with COVID-19 and High-Risk Genotype.

Background: Kidney involvement is a feature of COVID-19 and it can be severe in Black patients. Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 () variants that are more common in those of African descent.

Methods: To investigate genetic, histopathologic, and molecular features in six Black patients with COVID-19 presenting with AKI and nephrotic-range proteinuria, we obtained biopsied kidney tissue, which was examined by hybridization for viral detection and by NanoString for COVID-19 and acute tubular injury-associated genes.