Publications by authors named "Mark A Gohdes"
Article Synopsis
- - Lenacapavir (LEN) is a long-acting injectable drug approved for treating HIV-1, notable for its dual atropisomeric form that maintains a stable ratio in the bloodstream despite rapid interconversion.
- - The drug shows low systemic clearance in humans and animals, with a primary elimination route through fecal excretion rather than urine, while its concentration remains stable in plasma.
- - The study reveals that LEN does not enter the brain due to its interaction with P-glycoprotein and emphasizes the significance of intestinal excretion (IE) for drugs that are metabolically stable and eliminated slowly.
This paper describes a new strategy that utilizes the fast trap mode scan of the hybrid triple quadrupole linear ion trap (QqQ(LIT)) for the identification of drug metabolites. The strategy uses information-dependent acquisition (IDA) where the enhanced mass scan (EMS), the trap mode full scan, was used as the survey scan to trigger multiple dependent enhanced product ion scans (EPI), the trap mode product ion scans. The single data file collected with this approach not only includes full scan data (the survey), but also product ion spectra rich in structural information.
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