What is better for psychiatry: Titrated or fixed concentrations of nitrous oxide?

Medication dosages are crucial-no single dose fits all. My paper compares the safety, scientific and practical applicability of fixed 25-50% concentrations of nitrous oxide (NO) with the variable titrated concentrations of Psychotropic Analgesic NO (PAN), as used in dentistry, and neuropsychiatry. A crucial difference is that PAN is always titrated, an open circuit (nasal mask), to the concentration (dose), which ensures full consciousness, cooperation, comfort and relaxation.

Mini-Review: A Brief History of Nitrous Oxide (N2O) Use in Neuropsychiatry.

Background: Joseph Priestley's discovery of nitrous oxide (N2O) was recorded in 1772. In the late 1790's, Humphry Davy experimented with the psychotropic properties of N2O, describing his observations in a book, published in 1800. A dentist, Horace Wells discovered anaesthesia with N2O in 1844.

Combined cannabis/methaqualone withdrawal treated with psychotropic analgesic nitrous oxide.

This article reports the first single-blind study using psychotropic analgesic nitrous oxide (PAN) for treating acute withdrawal states following the abuse of methaqualone combined and smoked with cannabis. Smoked methaqualone combined with cannabis is called "white pipe" (WP). South Africa is the only country in the world where WP is a major form of substance abuse.

Psychotropic analgesic nitrous oxide for acute cocaine withdrawal in man.

This article reports the first single-blind study using psychotropic analgesic nitrous oxide (PAN) for treating acute withdrawal states following cocaine abuse. Thirty-one of the 33 cases responded by a reduction of symptom scores of 50% or more, which clinical experience has shown to be synonymous with observed recovery. Five subjects were placebo responders without further improvement following PAN.

Enlarged double-blind randomised trial of benzodiazepines against psychotropic analgesic nitrous oxide for alcohol withdrawal.

We report a randomised double-blind controlled study with an enlarged cohort of participants (N = 51) using psychotropic analgesic nitrous oxide (PAN) versus benzodiazepines (BZs) for treating acute alcoholic withdrawal states. An additional 28 participants having received a BZ the night previous to the study were pooled with the previously analysed 23 (with no additional BZ). These pooled results showed that PAN is superior to a BZ regimen at P = .

Randomized double-blind trial of psychotropic analgesic nitrous oxide compared with diazepam for alcohol withdrawal state.

In this article, we report the first randomized double-blind controlled study of the use of psychotropic analgesic nitrous oxide (PAN) vs. a single dose of benzodiazepine (diazepam) for treating acute alcoholic withdrawal states. In previous studies, it was demonstrated that a single treatment of PAN was sufficient to reverse 90% of acute alcoholic withdrawal states within the first 60 minutes of administration with lasting effect in a single-blind manner.