Ethnic differences in the biological consequences of alcohol abuse: a comparison between south Asian and European males.

Twenty-two South Asian men and 32 European men who had abused alcohol for at least 1.5 years were studied at the time of admission for detoxification to an Alcohol and Drug Dependency unit. The self-confessed average alcohol consumption during the preceding 3 months was similar in the South Asians (mean 383 g/day) and Europeans (mean 435 g/day) but the total duration of alcohol abuse was significantly shorter in South Asians (geometric mean 7.

Correlations between acetaldehyde-modified haemoglobin, carbohydrate-deficient transferrin (CDT) and haematological abnormalities in chronic alcoholism.

Serum levels of carbohydrate-deficient transferrin (CDT), the proportions of eight haemoglobin fractions separated by cation exchange liquid chromatography, indices of liver function and various haematological parameters were determined in most of a group of 49 chronic alcoholics who had misused alcohol for at least the preceding 3 months and in 15 healthy non-alcoholic control subjects. The percentages of alcoholics giving abnormally high values for gamma-glutamyl transferase (GGT) activity, CDT levels, GGT activity or CDT levels or both, and aspartate aminotransferase (AST) activity were, respectively, 73.0, 71.

Ethnic differences in the consequences of alcohol misuse.

The drinking habits of Asian and indigenous patients receiving in-patient care for alcoholism in West London were studied. Although both racial groups reported similar levels of current alcohol intake, the Asian developed problems and presented for in-patient detoxification with a shorter mean duration of drinking than the indigenous subjects. Values for mean corpuscular volume (MCV) and gamma glutamyl transpeptidase (GGT) were higher in the Asians, suggesting the Asians were at greater risk of alcohol-related physical damage.

Alcohol-related admissions to a psychiatric hospital: a comparison of Asians and Europeans.

The prevalence of alcohol-related problems in the British Asian community is unknown. We obtained details of all patients living in Southall who had been admitted with a primary alcohol-related diagnosis to a psychiatric hospital from 1980 to 1987. We used 1981 census data to calculate overall and age-specific incidence rates for Asian and European men and woman, expressed per 10,000 subjects over the 7-year period.

Correlations between serum proteins modified by acetaldehyde and biochemical variables in heavy drinkers.

A strong and highly significant correlation was observed between serum aspartate transaminase (AST) activity and an index of the cytotoxic activity associated with serum proteins modified by acetaldehyde in a group of 24 heavy drinkers. A weaker but significant correlation (R = 0.564, p = 0.

Increased free-radical activity in alcoholics.

The identification of the main dieneconjugated "free-radical marker" in human serum led to a study of free-radical activity in chronic alcoholics. 66 patients were investigated immediately after alcohol withdrawal and over 1-4 weeks' follow-up. The control groups were 76 normal subjects, 78 patients with liver disease, 30 patients on long-term antiepileptic drug treatment, 9 pregnant women, and 99 unselected hospital patients.

Abnormal suppression of plasma cortisol during the intravenous infusion of dexamethasone to alcoholic patients.

In some cases the oral administration of dexamethasone to alcoholic patients has failed to cause a normal depression of plasma cortisol levels. Although alcoholics often show signs of intestinal malabsorption, the possibility that the dexamethasone was not fully absorbed has not previously been considered. To eliminate any question of malabsorption, ten male alcoholic patients were infused intravenously with dexamethasone (1 mg/h).

Platelet hyperaggregability during alcohol withdrawal.

Platelet function was assessed before and one week after acute alcohol withdrawal in eighteen male alcoholics. Compared to normal male controls, the platelets of the alcoholics were slightly hypoaggregable on admission but became hyperaggregable one week after commencement of alcohol withdrawal therapy. The changes were most noticeable in those patients who were alcoholaemic on admission and when using ADP or adrenaline as aggregating agents.

Detection of alcoholic cardiomyopathy by serum enzyme and isoenzyme determination.

Serum creatine kinase and lactate dehydrogenase isoenzymes were studied in 73 patients with alcoholism, including two patients with clinical alcoholic cardiomyopathy and 28 patients with haemodynamic evidence (systolic time interval abnormality) of disordered myocardial function. No isoenzyme abnormalities suggestive of myocardial injury were observed. We conclude that isoenzyme examination is unsuitable for the early detection of myocardial damage from alcohol.