Publications by authors named "Marjory Jolicoeur"
Article Synopsis
- The Prostate Cancer Study 5 (PCS5) aimed to compare the effectiveness and side effects of two types of radiotherapy: conventional fractionated radiotherapy (CFRT) and hypofractionated radiotherapy (HFRT) for high-risk prostate cancer patients.
- The study included 329 patients who were randomly assigned to receive either CFRT or HFRT, with the primary focus on comparing toxicity and secondary outcomes like survival rates over a 5-year median follow-up.
- Results showed no significant differences in overall survival or other survival metrics between the two treatments, suggesting that HFRT could be adopted as a new standard treatment option for high-risk patients.
Purpose: The occurrence of genitourinary (GU) toxicity is a common adverse event observed after external beam radiation therapy (EBRT) for prostate cancer (PCa). Recent findings suggest that the dose delivered to specific urinary organs at risk (OARs) such as the ureters, bladder trigone, and urethra is involved in the development of GU toxicity.
Methods And Materials: A multidisciplinary task force including 3 radiation oncologists, a uroradiologist, and a urologist was created in 2022.
Up to 50% of patients treated with radical surgery for localized prostate cancer may experience biochemical recurrence that requires appropriate management. Definitions of biochemical relapse may vary, but, in all cases, consist of an increase in a PSA without clinical or radiological signs of disease. Molecular imaging through to positron emission tomography has taken a preponderant place in relapse diagnosis, progressively replacing bone scan and CT-scan.
View Article and Find Full Text PDFPurpose: Clinical target volume (CTV) delineation for pelvic lymph nodes in prostate cancer is currently based on 3 consensus guidelines with some inherent discrepancies. To improve the reproducibility in nodal delineation, the Francophone Group of Urological Radiotherapy (Groupe Francophone de Radiothérapie Urologique [GFRU]) worked toward proposing an easily applicable, reproducible, and practice-validated contouring guideline for pelvic nodal CTV.
Methods And Materials: The nodal CTV data sets of a high-risk node-negative prostate cancer clinical case contoured by 86 radiation oncologists participating in a GFRU contouring workshop were analyzed.
Article Synopsis
- The study evaluates the safety of moderate hypofractionated radiation therapy (HF RT) compared to standard fractionation (SF RT) in high-risk prostate cancer patients, based on the hypothesis that HF RT may offer advantages due to prostate cancer's sensitivity to radiation.
- From February 2012 to March 2015, 329 high-risk patients participated in a trial, with participants randomized into HF and SF groups, both receiving androgen deprivation therapy, and researchers primarily focused on monitoring acute and delayed toxicity.
- Results indicated that while there were initially more acute gastrointestinal (GI) events in the HF group, this significance diminished over time; ultimately, no major differences in delayed GI-related adverse events were observed
Article Synopsis
- Long-term androgen deprivation therapy in men with high-risk prostate cancer is linked to a decrease in bone mineral density, but this does not significantly increase the risk of fractures.
- A study analyzed the bone mineral density changes after 28 months of therapy and supplementation with calcium and vitamin D in patients, revealing an average decrease of -3.2% across multiple sites without significant classification changes for most patients.
- The findings suggest that while there is a slight reduction in bone mineral density, calcium and vitamin D supplementation is generally effective in managing bone health for these patients on long-term therapy.
Purpose: Prostate bed (PB) irradiation is considered the standard postoperative treatment after radical prostatectomy (RP) for tumors with high-risk features or persistent prostate-specific antigen, or for salvage treatment in case of biological relapse. Four consensus guidelines have been published to standardize practices and reduce the interobserver variability in PB delineation but with discordant recommendations. To improve the reproducibility in the PB delineation, the Francophone Group of Urological Radiotherapy (Groupe Francophone de Radiothérapie Urologique [GFRU]) worked to propose a new and more reproducible consensus guideline for PB clinical target volume (CTV) definition.
View Article and Find Full Text PDFPurpose: To evaluate the feasibility of supine breast magnetic resonance imaging (MR) for definition and localization of the surgical bed (SB) after breast conservative surgery. To assess the inter-observer variability of surgical bed delineation on computed tomography (CT) and supine MR.
Materials And Methods: Patients candidate for breast brachytherapy and no contra-indications for MR were eligible for this study.
Background: Increasing clinical data supports a low α/β ratio for prostate adenocarcinoma, potentially lower than that of surrounding normal tissues. A hypofractionated, weekly radiation therapy (RT) schedule should result in improved tumour control, reduced acute toxicity, and similar or decreased late effects. We report the toxicity profile of such treatment.
View Article and Find Full Text PDFPurpose: To evaluate quality of life (QOL) and outcome of patients with anal carcinoma treated with short split-course chemoradiation (CRT).
Methods: From 1991 to 2005, 58 patients with anal cancer were curatively treated with CRT. External beam radiotherapy (52 Gy/26 fractions) with elective groin irradiation (24 Gy) was applied in 2 series divided by a median gap of 12 days.
Objective: To evaluate the outcome of patients with recurrent vaginal endometrial cancer treated with high-dose-rate brachytherapy (HDRB) and external beam radiation therapy (EBRT).
Materials And Methods: The records of all patients diagnosed with endometrial cancer who had presented an isolated vaginal recurrence in our institution between January 1, 1997 and December 30, 2003 were reviewed. Twenty-two patients were identified; 18 (82%) received both EBRT and HDRB, and 4 (18%) received HDRB only.