Publications by authors named "Marjorie L Cang"
Article Synopsis
- Multi-drug resistant tuberculosis (MDR-TB) and extremely drug resistant TB (XDR-TB) are significant global health issues, prompting the development of innovative therapeutic vaccines like HSP65-vaccine, granulysin-vaccine, and Ksp37-vaccine.
- The HSP65-vaccine demonstrated a strong therapeutic effect against both MDR-TB and XDR-TB in mice, with intradermal immunization being more effective than other methods, and achieving enhanced results when combined with the antibiotic Isoniazid.
- Research on Ksp37 and granulysin vaccines in transgenic mice showed resistance to TB infection, highlighting the potential of combining DNA vaccines or using them alongside antibiotics
Results: HSP65 + IL-12 DNA vaccine showed higher protective efficacy compared with BCG in both mouse and monkey models of TB. It induced the TB-specific CTL in the mouse model of TB, while little level of activity was observed after the injection of BCG. It also showed strong therapeutic efficacy against MDR-TB.
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