Publications by authors named "Marjolein Hensens"
Signaling through chemokine receptor CXCR3 in the brain has been implicated in various brain diseases, as CXCR3 and its ligands are found under these conditions. Recently, a new chemokine ligand for CXCR3 was reported. In humans, an alternatively spliced variant of CXCR3 expressed on microvascular endothelial cells, named CXCR3b, was shown to bind CXCL4.
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- * The research identifies that injured neurons release the chemokine CCL21, which is stored in vesicles and transported to presynaptic areas, suggesting a signaling role in microglial activation.
- * CCL21 activates microglia through the CXCR3 receptor, implying that this pathway could explain how microglia are activated far from the actual injury site.