Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma.

Aims: To evaluate and compare the prognostic value and reproducibility of different methods of pattern of invasion scoring in oral squamous cell carcinomas. The additional prognostic value to established histopathological prognostic factors was also analysed.

Methods And Results: The study group was confined to 211 previously untreated patients who underwent surgery for low-stage oral squamous cell carcinoma between 1997 and 2008.