Midlife healthy-diet index and late-life dementia and Alzheimer's disease.

Aim: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD).

Methods: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components.

Caffeine as a protective factor in dementia and Alzheimer's disease.

Caffeine has well-known short-term stimulating effects on central nervous system, but the long-term impacts on cognition have been less clear. Dementia and Alzheimer's disease (AD) are rapidly increasing public health problems in ageing populations and at the moment curative treatment is lacking. Thus, the putative protective effects of caffeine against dementia/AD are of great interest.

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.

Caffeine stimulates central nervous system on a short term. However, the long-term impact of caffeine on cognition remains unclear. We aimed to study the association between coffee and/or tea consumption at midlife and dementia/Alzheimer's disease (AD) risk in late-life.

Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.

Objective: To investigate the association of midlife dietary fat intake to cognitive performance, and to the occurrence of clinical mild cognitive impairment (MCI) later in life in a non-demented population.

Design: A longitudinal population-based study.

Setting: Populations of Kuopio and Joensuu, Eastern Finland.