Publications by authors named "Marjan Mm Weiss"
Article Synopsis
- Epigenetic integrity is essential for cellular processes, and lysine acetyltransferase 8 (KAT8) plays a key role in acetylating histone H4 at lysine 16, which is vital for brain development and disease regulation.
- A study on cerebrum-specific knockout mice showed that the absence of KAT8 leads to cerebral hypoplasia and improper development of neural stem and progenitor cells, resulting in faulty cell proliferation and increased cell death.
- The research also identified nine patients with intellectual disabilities and related issues due to variants in the KAT8 gene, linking impaired H4K16 acetylation to their conditions and suggesting valproate as a potential treatment for epilepsy in some cases
