Publications by authors named "Marja van Veen-Sijne"
Article Synopsis
- Newborn screening (NBS) for congenital hypothyroidism (CH) in the Netherlands uses measurements of T4, TSH, and TBG, but recent evaluations revealed low positive predictive value (PPV) for the detection of central CH (CH-C).
- A study analyzed heel puncture cards from 1,670 infants, establishing new reference intervals (RIs) for these tests and identifying that almost half of false positives stemmed from partial TBG deficiency.
- Incorporating these RIs into the NBS algorithm can reduce unnecessary referrals without compromising the sensitivity of the screening for CH.
