Publications by authors named "Mariya Kosturkova"
Introduction: Lupus nephritis (LN) is a disease marked by autoantibodies against complement components. Autoantibodies against negative complement regulator factor H (anti-FH) are prevalent in aHUS, are associated with deletion of factor H-related protein 1 (FHR1) gene, and have overt functional consequences. They are also observed in C3 glomerulopathies.
View Article and Find Full Text PDFAutoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury. C1q, the recognition subcomponent of the complement classical pathway, forms a heterotetrameric complex with C1r and C1s, and can also associate a central complement regulator and C1 Inhibitor (C1-Inh). However, the frequency and the pathogenic relevance of anti-C1r, anti-C1s and anti-C1-Inh autoantibodies remain poorly studied in LN.
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- The study investigated the association between specific SNPs in the C1q gene cluster and rheumatoid arthritis (RA), focusing on five SNPs (rs665691, rs682658, rs172378, rs292001, and rs294179).
- Researchers found that certain genotypes of rs172378 and rs292001 were significantly associated with RA, indicating potential genetic links to the disease.
- Additionally, RA patients showed lower levels of C1q protein compared to healthy controls, supporting previous findings about immune response differences between these groups.
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). LN often leads to kidney failure, affecting the quality of a patient's life. There are several classical biomarkers that assist nephrologists' daily practice.
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