Publications by authors named "Mariya A Skryl'nikova"
A novel method for synthesizing 1,2,4-triazole- and tetrazole-containing 4-thiopyrano[2,3-]quinolines using a new combination of the thio-Michael and aza-Morita-Baylis-Hillman reactions was developed. Target compounds were evaluated for their cytotoxicities and antiviral activities against influenza A/Puerto Rico/8/34 virus in MDCK cells. The compounds showed low toxicity and some exhibited moderate antiviral activity.
View Article and Find Full Text PDFNovel [1,2,4]triazolo[3,4-][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity.
Andrey V Khramchikhin Mariya A Skryl'nikova Iana L Esaulkova Ekaterina O Sinegubova Vladimir V Zarubaev
Molecules
November 2022
Article Synopsis
- The study investigates the interaction of specific compounds (binucleophilic 3-substituted 4-amino-4H-1,2,4-triazole-5-thiols and 3-phenyl-2-propynal) to develop new synthetic approaches for certain isomeric classes of compounds.
- Out of 20 compounds tested against the H1N1 virus, half showed a selectivity index (SI) of 10 or higher, with one compound achieving an SI greater than 300, indicating strong antiviral potential.
- Docking studies suggest that the compounds primarily interact with the M2 proton channel of the influenza A virus, and modeling indicates that the aliphatic portions of the lig