Sialic acids in squamous cell carcinoma of the head and neck.

Altered glycosylation is a universal characteristic of cancer cells, and various types of glycan structures are well‑known markers of tumor progression and invasion. The present article discusses this aspect of the role of sialic acid, biosynthesis of sialylglycoconjugates and the genetic basis of its disorder, as well as the effects and the correlation between altered sialylation and clinical prognosis in head and neck squamous cell carcinoma (HNSCC). Only a few studies concerning the level of sialic acid in head and neck tumors have been conducted so far.

[The concentration of the chosen smoke toxicity biomarkers among smokers suffering from larynx cancer].

Introduction: An incidence of laryngeal cancer is strongly connected with exposure to tobacco smoke containing dozens of carcinogens. Genotoxic agents such as polycyclic aromatic hydrocarbons present in tobacco smoke are responsible for lesions of structure DNA and formation of DNA adducts by metabolically activated intermediates. Detecting the presence of DNA adducts in human tissues is therefore, a tool for studies of cancer.