Screening Papaveraceae as Novel Antibiofilm Natural-Based Agents.

The antimicrobial properties of herbs from Papaveraceae have been used in medicine for centuries. Nevertheless, mutual relationships between the individual bioactive substances contained in these plants remain poorly elucidated. In this work, phytochemical composition of extracts from the aerial and underground parts of five Papaveraceae species ( L.

Phytochemical Composition and Antimicrobial Activity of and .

and are two closely related genera from the subfamily with () and () as two representative species. Phytochemical analysis revealed significant differences in the quality and quantity of isoquinoline alkaloids, phenolic compounds and non-phenolic carboxylic acids between aerial and underground parts of both species. Using the Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) technique, 21 compounds were identified: five protoberberine derivatives, three protopine derivatives, four phenanthridine derivatives, as well as three carboxylic acids, two hydroxycinnamic acids, one chlorogenic acid, one phenolic aldehyde, and two flavonoids.

Modulatory Effect of Extract and Its Alkaloids on LPS-Stimulated Cytokine Secretion in Human Neutrophils.

Due to certain differences in terms of molecular structure, isoquinoline alkaloids from engage in various biological activities. Apart from their well-documented antimicrobial potential, some phenanthridine and protoberberine derivatives as well as extract present with anti-inflammatory and cytotoxic effects. In this study, the LC-MS/MS method was used to determine alkaloids, phenolic acids, carboxylic acids, and hydroxybenzoic acids.