Effect of some newly synthesized xanthone and piperazine derivatives with cardiovascular activity on rheology of human erythrocytes in vitro.

This in vitro study was designed to examine the effect of some newly synthesized aminoalcanolic derivatives of xanthone (I, II) and aroxyalkyl derivatives of 2-methoxyphenylpiperazine (III, IV) having cardiovascular activity on the haemorheological parameters of RBCs from healthy individuals and patients with chronic venous disease. Additionally, the influence of compounds I-IV on some RBCs associated enzymes such as acetylcholinesterase (Ache), glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase (GR) as well as glutathione (GSH) content were determined in vitro in RBCs from healthy subjects. The study showed that compounds I, III and IV significantly increased RBCs deformability.

Effect of Micronized Purified Flavonoid Fraction Therapy on Endothelin-1 and TNF-α Levels in Relation to Antioxidant Enzyme Balance in the Peripheral Blood of Women with Varicose Veins.

Objective: The aetiology of varicose veins involves various factors and pathomechanisms including endothelial cell activation or dysfunction, venous hypertension, vein wall hypoxia, shear stress disturbances, inflammatory reaction activation or free radical production. To improve our understanding of the mechanisms of potential pharmacological interventions for chronic venous disease, we evaluated the influence of micronized purified flavonoid fraction (MPFF) on the relationship between antioxidant enzyme balance, endothelin-1 (ET-1) and tumour necrosis factor-α (TNF-α) levels.

Material And Methods: Blood samples were obtained from 89 women with primary varicose veins; 34 were treated with MPFF and 55 did not receive any phlebotropic drug treatment.

Red blood cell deformability and aggregation in chronic venous disease patients with varicose veins.

Introduction: Red blood cells' (RBC) rheological properties are disturbed in chronic venous disease (CVD). The aim of the study was to compare deformability and aggregation of erythrocytes taken from the varicose vein and the antecubital vein of patients with chronic venous disease.

Materials And Methods: Blood samples were taken from twelve CVD patients presenting clinical, aetiological, anatomical and pathological elements (CEAP) stages II and III.

Rheological properties of young and aged erythrocytes in chronic venous disease patients with varicose veins.

We hypothesize that heterogeneity in RBC rheology can be attributed not only to the aging process but also to various disease states. The present study aims at investigating the rheological properties of young and old RBC in chronic venous disease (CVD) patients. RBC were separated on the basis of their density.

In vitro effect of pentoxifylline and lisofylline on deformability and aggregation of red blood cells from healthy subjects and patients with chronic venous disease.

Purpose. The aim of the study was to assess the in vitro potency of pentoxifylline (PTX) and one of its most active metabolites lisofylline (LSF) to improve rheological properties of red blood cells (RBC) from healthy individuals and patients with chronic venous disease (CVD). Additionally, the study aimed to compare the effects of PTX and LSF on RBC deformability and aggregation.

Iron content (PIXE) in competent and incompetent veins is related to the vein wall morphology and tissue antioxidant enzymes.

Impaired venous drainage of the lower extremities determines a cascade of pathologic events leading to chronic venous disease (CVD). It is believed that the one cause of CVD is red blood cell extravasation and local iron overload that could generate free radicals and iron-dependent inflammation. The aim of this study was to investigate the relationship between: the intracellular iron deposits in varicose veins and tissue oxidative state measured by: the Proton Induced X-ray Emission Spectroscopy (Fe(PIXE)), (tSOD), (tGPx), (tTBARs) and (boxDNA).

Oxidative DNA Damage in Blood of CVD Patients Taking Detralex.

The main goal of the work reported here was to determine the degree of oxidative/alkali-labile DNA damages in peripheral blood as well as in the blood stasis from varicose vein of (chronic venous disorder) CVD patients. Moreover, determination of the impact of Detralex usage on the level of (oxidative) DNA damages in CVD patients was evaluated as well.The degree of oxidative DNA damages was studied in a group consisted of thirty patients with diagnosed chronic venous insufficiency (CVI) in the 2nd and 3rd degree, according to clinical state, etiology, anatomy and pathophysiology (CEAP), and qualified to surgical procedure.

Generation of reactive oxygen species by a sufficient, insufficient and varicose vein wall.

Despite numerous theories, the etiology and pathogenesis of primary varicose veins remain unclear. The etiology of chronic venous diseases (CVDs) known as chronic venous insufficiency (CVI) is related to leukocyte trapping. Leukocyte trapping involves trapping of white cells in vessel walls followed by their activation and translocation outside the vessel.

[Role of Zn, Cu--trace elements and superoxide dismutase (SOD) in oxidative stress progression in chronic venous insufficiency (CVI)].

Introduction: Ions of trace elements, zinc and copper, play a key role in a number of vital signs and metabolic processes occurring in human organism. In venous vessels, Cu and Zn ions contribute to formation of free oxygen radicals (catalysts for Habera-Weisa reaction) and may result in development of changes leading to chronic venous disease (CVD), also known as chronic venous insufficiency (CVI). These elements lead to changes occurring in cells by contributing to lipid peroxidation process.

[Obesity and its' influence on reactive oxygen species (ROS) in the blood of patients with varicose veins of the lower limbs].

Introduction: Oxidative stress is considered as a probable mechanism in the pathogenesis and development of many diseases, including chronic venous disease (CVD). Local increased production of reactive oxygen species is taken into account as a mediator in vessel wall changes leading to damage of the endothelium and may be the mechanism leading to its' decreased blood flow and venous stasis. Obesity is a known clinical factor influencing venous blood flow from the lower limbs.

[Risk and prophylaxis of venous thromboembolism in the material of 2nd Chair of Surgery JUMC].

Introduction: Venous thromboembolism (VTE) is one of the most dangerous complication that could occur in patiens treated in surgical ward. Threat is increased due to presence of additional, apart from surgical procedures, risk factors. It is assesed, that approximately 50 000 patients are at risk of VTE yearly in Poland, 20 000 of them develop pulmonary thromboembolism during hospitalisation, which is fatal in 10% of cases.

[Surgical treatment of the lower extremities varicose veins throughout the ages].

The authors describe a historical review of surgical treatment of varicose veins from antiques to modern methods. Diseases of the veins have been recognized and attempts of their surgical resection have been described since antiquity. Hippocrates wrote about surgical treatment of varicose veins, Celsus and also Galien himself described varicose veins ligatures.

[Petit's triangle hernia clinically mimicking gluteal abscess].

Lumbar hernias are a very uncommon variety of abdominal wall defects. Diagnosis similar as obturatory hernia is often delayed until laparotomy. We describe a case of a 58 year old woman with parietal incarceration of the descending colon within a hernia in the inferior lumbar triangle (Petit's), under clinical form of a giant gluteal abscess.

[Surgical treatment of chronic venous insufficiency in own material].

Nowadays most issues regarding venous disorders are described as chronic venous insufficiency (CVI)-which is defined as all symptoms that manifestate as impaired blood outflow from the lower limbs or in general the result of blood stasis in the deep and superficial venous system. Due to the fact that the symptomatology of venous diseases is wide, the treatment should be multioriented and often as well multi-specialized. The treatment of CVI needs a good understanding of the etiology of the primary insufficiency of the superficial and the deep venous systems.