Merkel cell carcinoma - description of five cases.

Merkel cell carcinoma (MCC) is a rare but very aggressive skin cancer that derives from neuroendocrine cells of the skin. Merkel cell carcinoma morbidity has been continuously increasing for the last few years. Increasing reported incidence of MCC is probably connected with increasing occurrence of this kind of malignancy or with development of histological and immunohistochemical methods of sample examinations which have allowed for more precise diagnosis of skin tumor that might have previously not been accurately recognized.

Serum leptin and ghrelin levels in premenopausal women with stable body mass index during treatment of thyroid dysfunction.

Background: There are potentially complex interrelationships between thyroid function, leptin, ghrelin, body mass index (BMI), and percentage of body fat (%BF). The goal of this study was to determine if normalization of thyroid status in premenopausal women with hyperthyroidism and hypothyroidism would be associated with changes in serum leptin and ghrelin in the absence of thyroid dysfunction treatment-associated changes in BMI and %BF.

Methods: The study was carried out in 47 selected premenopausal women: 17 with hyperthyroidism, 11 with hypothyroidism, and 19 healthy individuals who constituted the control group.

[Early gastric carcinoma--a case report: removal of gastric polyp in a 50-year-old man].

Early gastric cancer is one of the most often neoplasma. The most of incidence of gastric cancer occur after 50 year of life. Poland is a country with high morbidity of gastric cancer in Europe.

[Is use of nitric oxide (NO) synthase inhibitors justified for therapy of septic shock?].

NO mediates many systemic reactions in humans and animals. It is produced by constitutive synthases (cNOS) and one inducible by cytokines and endotoxines (iNOS). We summarize, on the base of experimental and clinical data, the pathophysiological role of NO in septic shock as well as the effects of pharmacological application of NOS inhibitors.