Publications by authors named "Mariusz A Kusztal"
Article Synopsis
- - The study investigates how hemodialysis affects the oxygen-binding ability of hemoglobin (measured by p50) in patients with chronic kidney disease (CKD) and explores the relationship between p50 and various blood parameters.
- - A total of 180 CKD patients were analyzed, dividing them into hemodialysis (HD) and non-hemodialysis (non-HD) groups, finding that HD patients required higher doses of erythropoietin but had similar hemoglobin levels compared to non-HD patients.
- - Results indicated that non-HD patients experienced more severe metabolic acidosis and lower blood pH, while p50 values differed significantly between the two groups, suggesting a potential impact of dialysis on oxygen delivery
Article Synopsis
- Fabry disease (FD) is a rare, genetic disorder caused by enzyme deficiencies that lead to multiple organ dysfunction and can result in premature death, affecting both males and females.
- Enzyme replacement therapy, including agalsidase and oral chaperone migalastat, is utilized for managing FD, with migalastat being effective for 35-50% of patients with specific gene variants.
- This position statement presents a comprehensive review of migalastat’s role in FD treatment, including its pharmacology, clinical trial evidence on safety and effectiveness, and practical guidelines for clinicians regarding patient selection and diagnostic testing.
The damage to small vessels in AAV and inflammatory reactions are accompanied by the release of various chemokines and cytokines. Using a flow cytometry technique, we assessed the levels of specific cytokines, namely IL-1β IL-6, IL-8, IL-10, IL12p70, and TNF, and chemokines, IFN-α, IP-10, and MIG in the serum from 9 healthy volunteers and 20 AAV patients, where 11 of the patients were not treated and evaluated at the time of diagnosis and 9 were already diagnosed and taking CY + GCS. The obtained results were then compared considering the activity of the disease, the type and titre of the ANCA antibodies, the inflammatory status, and the kidneys' condition.
View Article and Find Full Text PDFHyponatremia is one of the most common water-electrolyte imbalances in the human organism. A serum sodium concentration threshold of less than 135 mmol/L is diagnostic for hyponatremia. The disorder is usually secondary to various diseases, including infections.
View Article and Find Full Text PDFType 1 diabetic patients have better endothelial function after simultaneous pancreas-kidney transplantation than after kidney transplantation with continued insulin therapy.
Diab Vasc Dis Res
March 2018
The purpose of this study was to analyse the influence of simultaneous pancreas-kidney or kidney transplantation on endothelial function and systemic inflammation in type 1 diabetic patients with end-stage renal disease. In 39 simultaneous pancreas-kidney, 39 type 1 diabetic kidney and 52 non-diabetic kidney recipients, flow-mediated dilatation was measured. Additionally, blood glycated haemoglobin, serum creatinine and lipids, plasma nitrites [Formula: see text] and nitrates, asymmetric dimethylarginine, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin, high-sensitivity C-reactive protein, tumour necrosis factor-α, interleukin 1β and interleukin 6 concentrations were assessed.
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